![](/CAS/GIF/34884-10-1.gif)
1-Methylpyrrole-2-carbonitrile synthesis
- Product Name:1-Methylpyrrole-2-carbonitrile
- CAS Number:34884-10-1
- Molecular formula:C6H6N2
- Molecular Weight:106.13
![N-Methyl pyrrole](/CAS/GIF/96-54-8.gif)
96-54-8
266 suppliers
$5.00/1g
![Chlorosulfonyl isocyanate](/CAS/GIF/1189-71-5.gif)
1189-71-5
341 suppliers
$18.00/5g
![1-Methylpyrrole-2-carbonitrile](/CAS/GIF/34884-10-1.gif)
34884-10-1
87 suppliers
$45.95/250mgs:
Yield: 95%
Reaction Conditions:
Stage #1:N-Methylpyrrole;isocyanate de chlorosulfonyle in toluene at -6 - 0; for 0.25 h;
Stage #2: with triethylamine;N,N-dimethyl-formamide in toluene at -4 - 10;Product distribution / selectivity;
Steps:
2
Starting with 47.0 g of 1-methylpyrrole, the reaction was conducted in a manner generally analogous to Example 1 except that the acetonitrile was replaced with toluene. After addition of chlorosulfonyl isocyanate, two layers were formed. Upon cooling to 0 to 5 C., the bottom layer solidified. The hygroscopic solids were collected by filtration and washed with toluene. Concentration of the filtrates gave 325 mL of a toluene solution containing (as determined by 1H NMR) 0.55 mol of 1-methylpyrrole-2-carbonitrile (58.3 g, 95% yield).
References:
Wyeth US2005/222432, 2005, A1 Location in patent:Page/Page column 2
![1-Methyl-1H-pyrrole-2-carbaldehyde oxime](/CAS/20140525/GIF/CB52479106.gif)
37110-15-9
11 suppliers
$60.00/100mg
![1-Methylpyrrole-2-carbonitrile](/CAS/GIF/34884-10-1.gif)
34884-10-1
87 suppliers
$45.95/250mgs:
![N-Methylpyrrole-2-carboxaldehyde](/CAS/GIF/1192-58-1.gif)
1192-58-1
174 suppliers
$9.00/5g
![1-Methylpyrrole-2-carbonitrile](/CAS/GIF/34884-10-1.gif)
34884-10-1
87 suppliers
$45.95/250mgs:
![PYRROLE-2-CARBONITRILE](/CAS/GIF/4513-94-4.gif)
4513-94-4
199 suppliers
$15.00/1g
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
342 suppliers
$15.00/10g
![1-Methylpyrrole-2-carbonitrile](/CAS/GIF/34884-10-1.gif)
34884-10-1
87 suppliers
$45.95/250mgs:
![PYRROLE-2-CARBONITRILE](/CAS/GIF/4513-94-4.gif)
4513-94-4
199 suppliers
$15.00/1g
![Dimethyl carbonate](/CAS/GIF/616-38-6.gif)
616-38-6
661 suppliers
$5.00/5 g
![1-Methylpyrrole-2-carbonitrile](/CAS/GIF/34884-10-1.gif)
34884-10-1
87 suppliers
$45.95/250mgs: