![](/CAS/GIF/119018-29-0.gif)
4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide synthesis
- Product Name:4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
- CAS Number:119018-29-0
- Molecular formula:C16H21N3O4S
- Molecular Weight:351.42
![4-{2-{[(3-Ethyl-2,5-dihydro-4-methyl-2-oxo-1H-pyrrol-1-yl)-carbonyl]-amino}-ethyl}-benzenesulfonyl chloride](/CAS/GIF/119043-16-2.gif)
119043-16-2
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![4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide](/CAS/GIF/119018-29-0.gif)
119018-29-0
251 suppliers
$17.00/1g
Yield:119018-29-0 97.8%
Reaction Conditions:
with ammonia in water at 80; for 1.5 h;
Steps:
1
120 g of chlorosulfonic acid was added to a three-necked bottle, and the compound m was added in portions. After the addition, the reaction was kept at 80 ° C for 0.5 hour. The reaction was completely monitored by TLC, and the temperature was lowered to 25 ° C. The reaction was dropped into ice water and filtered to obtain a solid. Adding solid to a solution of 200 ml of ammonia water and 100 ml of water, heating to 80 ° C for 1.5 hours, cooling to 30 ° C, adding hydrochloric acid to the reaction solution, separating the solid, filtering, washing with water, drying at 50 ° C, The obtained white solid was 25.2 g, and the purity by HPLC was 78.08%, the impurity V 7.24%, the impurity was 16.35%, and the yield was 97.8%.
References:
Weihai Disu Pharmaceutical Co., Ltd.;Disha Pharmaceutical Group Co., Ltd.;Wu Ronggui;Xue Fuzhao;Xu Keling;Wang Changde CN110092739, 2019, A Location in patent:Paragraph 0022
![3-Ethyl-4-methyl-3-pyrrolin-2-one](/CAS/GIF/766-36-9.gif)
766-36-9
324 suppliers
$8.00/5g
![4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide](/CAS/GIF/119018-29-0.gif)
119018-29-0
251 suppliers
$17.00/1g
![3-Ethyl-2,5-Dihydro-4-Methyl-2-Oxo-N-(2-Phenylethyl)-1h-Pyrrole-1-Carboxamide](/CAS/GIF/247098-18-6.gif)
247098-18-6
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![4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide](/CAS/GIF/119018-29-0.gif)
119018-29-0
251 suppliers
$17.00/1g
![Butanoic acid, 3-cyano-2-ethyl-3-hydroxy-, ethyl ester](/CAS/20200331/GIF/247098-17-5.gif)
247098-17-5
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![4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide](/CAS/GIF/119018-29-0.gif)
119018-29-0
251 suppliers
$17.00/1g
![Ethyl 2-ethylacetoacetate](/CAS/GIF/607-97-6.gif)
607-97-6
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$10.00/1g
![4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide](/CAS/GIF/119018-29-0.gif)
119018-29-0
251 suppliers
$17.00/1g