![](/CAS/20150408/GIF/1267610-26-3.gif)
1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone synthesis
- Product Name:1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
- CAS Number:1267610-26-3
- Molecular formula:C15H19N3O2
- Molecular Weight:273.33
![](/NewsImg/2021-12-20/6377561222084172108946429.jpg)
Add 25L of water and 25L of methanol to the 500L reactor, add 2.5kg of compound (I) and 250g of Raney cobalt under stirring, raise the temperature to 40-50 °C, slowly add 2.0kg of hydrazine hydrate (content 80%), keep warm 60-70 °C, reaction for 3h, the reaction was completed, filtered with diatomaceous earth, concentrated solvent was removed, and MTBE was added to the filter cake.2.20 kg of a white solid were obtained with a yield of 98% and a purity of 99.8%.
![3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one](/CAS2/GIF/503615-03-0.gif)
503615-03-0
319 suppliers
$31.00/1g
![1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone](/CAS/20150408/GIF/1267610-26-3.gif)
1267610-26-3
235 suppliers
$40.00/5g
Yield:1267610-26-3 98%
Reaction Conditions:
with hydrazine hydrate in methanol;water at 40 - 70; for 3 h;Large scale;Solvent;Temperature;
Steps:
2; 3; 4; 5; 6 Example 5
Add 25L of water and 25L of methanol to the 500L reactor, add 2.5kg of compound (I) and 250g of Raney cobalt under stirring, raise the temperature to 40-50 °C, slowly add 2.0kg of hydrazine hydrate (content 80%), keep warm 60-70 °C, reaction for 3h, the reaction was completed, filtered with diatomaceous earth, concentrated solvent was removed, and MTBE was added to the filter cake.2.20 kg of a white solid were obtained with a yield of 98% and a purity of 99.8%.
References:
Shanghai Haoyuan Pharmaceutical Co., Ltd.;Zhao Jian;Chen Kuaikuai;Yang Chengwu;Li Shuoliang;Gao Qiang;Zheng Baofu CN108503580, 2018, A Location in patent:Paragraph 0042-0051
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1575-61-7
348 suppliers
$14.00/1g
![1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone](/CAS/20150408/GIF/1267610-26-3.gif)
1267610-26-3
235 suppliers
$40.00/5g
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38560-30-4
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$11.00/250mg
![1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone](/CAS/20150408/GIF/1267610-26-3.gif)
1267610-26-3
235 suppliers
$40.00/5g
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1039914-85-6
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inquiry
![1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone](/CAS/20150408/GIF/1267610-26-3.gif)
1267610-26-3
235 suppliers
$40.00/5g
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62-53-3
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![1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone](/CAS/20150408/GIF/1267610-26-3.gif)
1267610-26-3
235 suppliers
$40.00/5g