3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one synthesis
- Product Name:3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one
- CAS Number:503615-03-0
- Molecular formula:C15H17N3O4
- Molecular Weight:303.31
110-91-8
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Yield:503615-03-0 90.4%
Reaction Conditions:
at 120; for 2 h;Inert atmosphere;
Steps:
1 Preparation of 1d
The 1c (19.0g, 65.7mmol) was dissolved in morpholine (100ml) to obtain a reaction mixture,reaction mixture at reflux for 2 hours 120 °C , reaction progress was followed by thin layer chromatography, the reaction was completed, vacuum distillation most morpholine was removed, the residue as a yellow solid which was washed with water stirred 1 hour, filtered, the filter cake washed three times, air-dried and dried 24 hours give 1d (18.0g, yellow solid), yield: 90.4%
References:
CN104650072,2016,B Location in patent:Paragraph 0122; 0125; 0135; 0136