![](/CAS/20150408/GIF/1276110-38-3.gif)
(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine synthesis
- Product Name:(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine
- CAS Number:1276110-38-3
- Molecular formula:C15H21IN6O2
- Molecular Weight:444.27
![(S)-1-(TERT-BUTOXYCARBONYL)PIPERIDIN-3-YL METHANESULFONATE](/CAS/GIF/940890-90-4.gif)
940890-90-4
39 suppliers
$68.00/250mg
![3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine](/CAS/GIF/151266-23-8.gif)
151266-23-8
331 suppliers
$22.00/1g
![(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine](/CAS/20150408/GIF/1276110-38-3.gif)
1276110-38-3
50 suppliers
$18.00/100mg
Yield: 79%
Reaction Conditions:
with caesium carbonate in N,N-dimethyl-formamide at 80;Inert atmosphere;
Steps:
1.B.4 Step 4: Preparation of (R)-3-(4-amino-3-iodo-1H-pyrazolo[3,4-d] pyrimidin-1-yl) piperidine-1-carboxylic acid tert-butyl ester
The 3-iodo--1H- pyrazolo [3,4-d] pyrimidin-4-ylamine (4.3g, 16.57mM, 1.0equiv) was dissolved in N, N- dimethylformamide (60mL),And cesium carbonate were sequentially added (6.753g, 35mM, 2.1equiv), (S) -3- (methanesulfonyloxy) piperidine-l-carboxylate (5.549g,19.88mM, 1.2equiv), and heated at 80 in nitrogen, after completion of the reaction by TLC, concentrated under reduced pressure most of the N, N- dimethylFormamide, was added water (60mL), and extracted with ethyl acetate (3 × 30), and the combined organic layers were washed with water, normal saline. The organic layer wasDried over anhydrous sodium sulfate, filtered and concentrated. Column chromatography (petroleum ether: ethyl acetate = 2: 1) to give a white solid after treatment Compound 4 (5.8g,79%).
References:
Chengdu Biological Technology Co. Ltd.;Li, De Qun CN105315283, 2016, A Location in patent:Paragraph 0015; 0016; 0017
![3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine](/CAS/GIF/151266-23-8.gif)
151266-23-8
331 suppliers
$22.00/1g
![(S)-1-Boc-3-hydroxypiperidine](/CAS/GIF/143900-44-1.gif)
143900-44-1
537 suppliers
$5.00/1g
![(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine](/CAS/20150408/GIF/1276110-38-3.gif)
1276110-38-3
50 suppliers
$18.00/100mg
![(S)-3-(Toluene-4-sulfonyloxy)-piperidine-1-carboxylic acid tert-butyl ester](/CAS/20120318/GIF/CB52576674.gif)
1353993-49-3
9 suppliers
$350.00/1 g
![3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine](/CAS/GIF/151266-23-8.gif)
151266-23-8
331 suppliers
$22.00/1g
![(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine](/CAS/20150408/GIF/1276110-38-3.gif)
1276110-38-3
50 suppliers
$18.00/100mg
![3-Iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine](/CAS/GIF/151266-23-8.gif)
151266-23-8
331 suppliers
$22.00/1g
![(R)-1-Boc-3-Hydroxypiperidine](/CAS/GIF/143900-43-0.gif)
143900-43-0
277 suppliers
$6.00/1g
![(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine](/CAS/20150408/GIF/1276110-38-3.gif)
1276110-38-3
50 suppliers
$18.00/100mg
![3-Iodo-3H-pyrazolo[3,4-d]pyriMidin-4-aMine](/CAS/20150408/GIF/570409-85-7.gif)
570409-85-7
22 suppliers
inquiry
![(S)-1-Boc-3-hydroxypiperidine](/CAS/GIF/143900-44-1.gif)
143900-44-1
537 suppliers
$5.00/1g
![(3R)-1-Boc-3-(4-aMino-3-iodo-1H-pyrazolo[3,4-d]pyriMidin-1-yl)piperidine](/CAS/20150408/GIF/1276110-38-3.gif)
1276110-38-3
50 suppliers
$18.00/100mg