ChemicalBook CAS DataBase List 1H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLIC ACID

1H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLIC ACID synthesis

5synthesis methods

Product Name:1H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLIC ACID
CAS Number:479553-01-0
Molecular formula:C8H6N2O2
Molecular Weight:162.15

344327-11-3 Synthesis

344327-11-3
190 suppliers
$12.00/250mg

1H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLIC ACID

479553-01-0
145 suppliers
$24.00/100mg

Yield: 100%

Reaction Conditions:

with ethanol;sodium hydroxide for 20 h;Reflux;

Steps:

2 Preparation Example 2: Preparation of 1H-pyrrole[2,3-b]pyridine-4-carboxylic acid
1H-pyrrole [2,3-b] pyridine-4-carbonitrile obtained in Preparation Example 1 above(100 mg, 0.70 mmol) was dissolved in ethanol (5 ml),Sodium hydroxide (10N, 350 μl, 3.5 mmol) was added and heated to reflux for 20 hours.After the reaction was terminated by adding water (30 ml), Sulfuric acid (93 ul, 1.75 mmol) was added for neutralization, and the resulting sodium sulfate was filtered.Next, the filtrate was concentrated under reduced pressure to obtain the title compound.(114 mg, 0.7 mmol, 100%, colorless oil) was obtained.

References:

Korea Research Institute of Chemical Technology KR101508214, 2015, B1 Location in patent:Paragraph 0168-0172

618446-36-9 Synthesis