![](/CAS/GIF/327056-62-2.gif)
2-Cyano-5-fluoropyridine synthesis
- Product Name:2-Cyano-5-fluoropyridine
- CAS Number:327056-62-2
- Molecular formula:C6H3FN2
- Molecular Weight:122.1
![5-Chloro-2-cyanopyridine](/CAS/GIF/89809-64-3.gif)
89809-64-3
256 suppliers
$14.00/5g
![2-Cyano-5-fluoropyridine](/CAS/GIF/327056-62-2.gif)
327056-62-2
257 suppliers
$5.00/1g
Yield:327056-62-2 425 mg (48%)
Reaction Conditions:
with potassium fluoride in 1-methyl-pyrrolidin-2-one
Steps:
1 5-Fluoropyrid-2-ylamidoxime
A mixture of 2-cyano-5-chloropyridine (1 g, 7.22 mmol) and potassium fluoride (1.26 g, 21.68 mmol) in 1-methyl-2-pyrrolidinone (25 mL) was heated at reflux for 18 hours. After cooling, the reaction was diluted with ethyl acetate and extracted with water and brine. The organic solvents were then removed in vacuo. Silica gel chromatography of the residue afforded 425 mg (48%) of 2-cyano-5-fluoropyridine.
References:
Wagenen, Bradford Van;Stormann, Thomas M.;Moe, Scott T.;Sheehan, Susan M.;McLeod, Donald A.;Smith, Daryl L.;Isaac, Methvin Benjamin;Slassi, Abdelmalik US2003/55085, 2003, A1
![3-Amino-6-cyanopyridine](/CAS/GIF/55338-73-3.gif)
55338-73-3
193 suppliers
$26.00/100mg
![2-Cyano-5-fluoropyridine](/CAS/GIF/327056-62-2.gif)
327056-62-2
257 suppliers
$5.00/1g
![ZINC CYANIDE](/CAS/GIF/557-21-1.gif)
557-21-1
86 suppliers
$12.00/5g
![2-Bromo-5-fluoropyridine](/CAS/20181212/GIF/41404-58-4.gif)
41404-58-4
397 suppliers
$5.00/1g
![2-Cyano-5-fluoropyridine](/CAS/GIF/327056-62-2.gif)
327056-62-2
257 suppliers
$5.00/1g
![2-Bromo-5-fluoropyridine](/CAS/20181212/GIF/41404-58-4.gif)
41404-58-4
397 suppliers
$5.00/1g
![ZINC CYANIDE](/CAS/GIF/557-21-1.gif)
557-21-1
86 suppliers
$12.00/5g
![2-Cyano-5-fluoropyridine](/CAS/GIF/327056-62-2.gif)
327056-62-2
257 suppliers
$5.00/1g
![5-Bromo-2-pyridinecarbonitrile](/CAS/20180808/GIF/97483-77-7.gif)
97483-77-7
550 suppliers
$10.00/5g
![2-Cyano-5-fluoropyridine](/CAS/GIF/327056-62-2.gif)
327056-62-2
257 suppliers
$5.00/1g