ChemicalBook CAS DataBase List 2-fluoro-4-(methylthio)benzonitrile

2-fluoro-4-(methylthio)benzonitrile synthesis

3synthesis methods

Product Name:2-fluoro-4-(methylthio)benzonitrile
CAS Number:411233-39-1
Molecular formula:C8H6FNS
Molecular Weight:167.2

101187-91-1
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74-88-4
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411233-39-1
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Yield:411233-39-1 100%

Reaction Conditions:

with potassium carbonate in acetonitrile at 20; for 3 h;

Steps:

AE.iv

Methyl iodide (12.5 g, 0.058 mol) was added dropwise to a solution of 2-fluoro-4-mercaptobenzonitrile (9 g, 0.058 mol) (from step (iii) above and potassium carbonate (12.1 g, 0.088 mol) in dry acetonitrile (150 ml) and stirred at room temperature for 3 h under nitrogen atmosphere. The reaction mixture was filtered and the filtrate was concentrated to give the sub-title compound (9.6 g, 100%)

References:

US2008/15237,2008,A1 Location in patent:Page/Page column 35-36

624-92-0 Synthesis