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2-Methyl-2-p-tolylpropanenitrile synthesis

7synthesis methods
-

Yield:40119-34-4 100%

Reaction Conditions:

Stage #1: (4-methylphenyl)acetonitrilewith sodium hydride in tetrahydrofuran at 0; for 1.5 h;Inert atmosphere;
Stage #2: methyl iodide in tetrahydrofuran at 0;Inert atmosphere;

References:

Srinivas, Dasari;Satyanarayana, Gedu [Organic Letters,2021,vol. 23,# 19,p. 7353 - 7358] Location in patent:supporting information