2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER synthesis
- Product Name:2-METHYLPYRIDINE-4-BORONIC ACID PINACOL ESTER
- CAS Number:660867-80-1
- Molecular formula:C12H18BNO2
- Molecular Weight:219.09
22282-99-1
387 suppliers
$6.00/5g
73183-34-3
563 suppliers
$6.00/5g
660867-80-1
159 suppliers
$11.00/250mg
Yield: 70%
Reaction Conditions:
with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium acetate in 1,4-dioxane at 90; for 12 h;Inert atmosphere;Miyaura Borylation Reaction;
Steps:
4.3. General methods for intermediates 6 and 10
General procedure: To a solution of borate (1 equiv) and bipinacol borate (1.2 equiv)in anhydrous dioxane, KOAc (3 equiv) and Pd(dppf)Cl2 (0.05% mol)were added. After reaction at 90 C for 12 h under N2 atmosphere,the solvent was concentrated and water was added to the reactionflask, and then the filter cake was washed with petroleum etherand acetonitrile to obtain the intermediates 6 and 10.
References:
Chen, Huanhua;Ding, Huaiwei;Gao, Yaping;Jiang, Xiaowen;Liu, Wenjie;Liu, Wenwu;Liu, Xin;Tian, Liting;Xu, Zihua;Zhao, Qingchun [European Journal of Medicinal Chemistry,2021,vol. 222]
3678-63-5
202 suppliers
$10.00/1g
73183-34-3
563 suppliers
$6.00/5g
660867-80-1
159 suppliers
$11.00/250mg
109-06-8
397 suppliers
$16.00/25g
73183-34-3
563 suppliers
$6.00/5g
660867-80-1
159 suppliers
$11.00/250mg
3678-63-5
202 suppliers
$10.00/1g
73183-34-3
563 suppliers
$6.00/5g
109-06-8
397 suppliers
$16.00/25g
660867-80-1
159 suppliers
$11.00/250mg