ChemicalBook CAS DataBase List 2-PHENYL-BENZOOXAZOL-5-YLAMINE

2-PHENYL-BENZOOXAZOL-5-YLAMINE synthesis

9synthesis methods

Product Name:2-PHENYL-BENZOOXAZOL-5-YLAMINE
CAS Number:41373-37-9
Molecular formula:C13H10N2O
Molecular Weight:210.23

137-09-7
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$32.47/25G

65-85-0 Synthesis

65-85-0
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41373-37-9
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$28.60/50mg

Yield:41373-37-9 97%

Reaction Conditions:

polyphosphoric acid at 110 - 180; for 3 h;

Steps:

1A; 14

To polyphosphoric acid at HO⁰C were added simultaneously 2,4-diaminophenol dihydrochloride (7.88g, 40mmol) and benzoic acid (4.88g, 40mmol). The resulting mixture was then heated to 18O⁰C for 3h. The solution was then poured into water. The resulting precipitate was collected by filtration and washed with saturated sodium bicarbonate solution. The crude product was recrystallised from ethanol/water to afford 8.15g (97%) of the title compound (LCMS RT= 5.17min, MH^4" 211.1) ¹H NMR (DMSO): 8.15-8.12 (2H, m), 7.60-7.56 (3H, m), 7.42 (IH, d, J 8.7 Hz), 6.89 (IH, d, J2.1 Hz), 6.68 (IH, dd, J8.6 2.2 Hz), 5.12 (2H, s)

References:

WO2007/91106,2007,A2 Location in patent:Page/Page column 51

891-43-0 Synthesis