3-[(2-CHLOROBENZYL)OXY]BENZALDEHYDE synthesis
- Product Name:3-[(2-CHLOROBENZYL)OXY]BENZALDEHYDE
- CAS Number:168084-94-4
- Molecular formula:C14H11ClO2
- Molecular Weight:246.69
611-17-6
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$9.00/1g
99-06-9
478 suppliers
$5.00/25g
168084-94-4
26 suppliers
$75.00/500 mg
Yield: 76.6%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 80; for 3 h;
Steps:
14.1 (1) 3 - (2 - chlorine animal pen oxygen radical) benzaldehyde preparation
The 3 - hydroxybenzaldehyde (0.50 g, 4 . 06 mmol) dissolved in 8 mLDMF in, adding 2 - chlorine animal pen bromine (1.00 g, 4 . 87 mmol), potassium carbonate (0.84 g, 6 . 08 mmol), 80 °C reaction 3 hours, adding 15 ml distilled water, extracted with ethyl acetate twice (2 × 20 ml), then saturated sodium chloride solution for washing 1 time, dried with anhydrous sodium sulfate. Concentrated, column chromatography, eluting agent is petroleum ether: ethyl acetate=3:1, to obtain white solid 0.77 g, yield 76.6%
References:
Chinese Academy Of Medical Sciences Pharmaceutical Institute;Wang Xiaojian;Sun Chenbin;Ge Jun;Xi Meiyang;Xiao Qiong;Yin Dali CN107151220, 2017, A Location in patent:Paragraph 0275; 0276; 0277; 0278; 0279
611-19-8
427 suppliers
$7.00/25g
100-83-4
621 suppliers
$5.00/10g
168084-94-4
26 suppliers
$75.00/500 mg
611-17-6
190 suppliers
$9.00/1g
100-83-4
621 suppliers
$5.00/10g
168084-94-4
26 suppliers
$75.00/500 mg