ChemicalBook CAS DataBase List 3-Bromobenzophenone

3-Bromobenzophenone synthesis

14synthesis methods

Product Name:3-Bromobenzophenone
CAS Number:1016-77-9
Molecular formula:C13H9BrO
Molecular Weight:261.11

3-Bromobenzophenone can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly in laboratory research. It can be synthesized by the substitution reaction between 3-Bromobenzoic acid and Benzene.

585-76-2 Synthesis

585-76-2
338 suppliers
$6.00/5g

71-43-2
673 suppliers
$11.19/25ML

1016-77-9
178 suppliers
$10.00/1g

Yield:1016-77-9 93%

Reaction Conditions:

Stage #1:m-bromobenzoic acid with thionyl chloride at 70; for 4 h;
Stage #2:benzene with aluminum (III) chloride in chloroform at 0 - 20; for 6 h;

Steps:

1 Specific Example 1. Preparation of 3-bromobenzophenone 1.
2 g of bromobenzoic acid was dissolved in 200 g of thionyl chloride and reacted at 70 ° C for 4 h. After completion of the reaction,The unreacted sulfoxylate was recovered under reduced pressure, and the residual thionyl chloride was blown in a nitrogen atmosphere, cooled to 0 ° in an ice bath,400 g of chloroform, 88 g of benzene and 140 g of anhydrous aluminum trichloride were added to the reaction system at room temperature for 6 hours. After the completion of the reaction, the reaction solution was slowly poured into a mixture of 500 ml of ice water and hydrochloric acid (100 ml) The residue was washed with water, dried over anhydrous sodium sulfate, and the solvent was recovered under reduced pressure. The crystals were recrystallized from toluene to give 240 g of a white solid in 93% yield.

References:

Jiangsu Engineering Polytechnic College;Feng Chengliang;Yin Guibo;Yan Bin CN106748723, 2017, A Location in patent:Paragraph 0034; 0048; 0049

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591-18-4 Synthesis