ChemicalBook CAS DataBase List 4-(1',1''-BIPHENYL-4'-YL)-CYCLOHEXANONE

4-(1',1''-BIPHENYL-4'-YL)-CYCLOHEXANONE synthesis

6synthesis methods

Product Name:4-(1',1''-BIPHENYL-4'-YL)-CYCLOHEXANONE
CAS Number:78531-65-4
Molecular formula:C18H18O
Molecular Weight:250.33

3-Cyclohexen-1-one, 4-[1,1'-biphenyl]-4-yl-

1345511-16-1
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78531-65-4
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Yield:78531-65-4 4.4 g

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in ethyl acetate at 20; under 3000.3 Torr; for 6 h;

Steps:

D119.3 Step 3: 4- ( [1, 1'-biphenyl] -4-yl) cyclohexan-1-one

To a solution of 2, 5-dihydro- [1, 1': 4', 1″-terphenyl] -4 (3H) -one (42 mmol) in ethyl acetate (200 mL) was added Pd/C (2.0 g, 10%) and the mixture was stirred for 6 hours at room temperature under H₂(0.4 Mpa) . Then filtered to remove Pd/C and the filtrate was evaporated under reduced pressure to give a crude product, which was washed with PE/EA=5: 1 to give 4.4 g (42%yield for three steps) product as white solid. [M+H]⁺=251.1.

References:

WO2018/54365,2018,A1 Location in patent:Paragraph 0586; 0589

4746-97-8 Synthesis