ChemicalBook CAS DataBase List 4-(1,3-THIAZOL-2-YL)BENZONITRILE

4-(1,3-THIAZOL-2-YL)BENZONITRILE synthesis

5synthesis methods

Product Name:4-(1,3-THIAZOL-2-YL)BENZONITRILE
CAS Number:672324-84-4
Molecular formula:C10H6N2S
Molecular Weight:186.23

288-47-1 Synthesis

288-47-1
282 suppliers
$6.00/1g

623-03-0 Synthesis

623-03-0
442 suppliers
$6.00/25g

672324-84-4
15 suppliers
inquiry

Yield:672324-84-4 91%

Reaction Conditions:

Stage #1: 1,3-thiazolewith n-butyllithium in tetrahydrofuran at -78;Inert atmosphere;
Stage #2: with zinc(II) chloride in tetrahydrofuran at -78 - 20; for 1.5 h;Inert atmosphere;
Stage #3: 4-Cyanochlorobenzenewith dichloro(1,3-bis(2,6-bis(3-pentyl)phenyl)imidazolin-2-ylidene)(3-chloropyridyl)palladium(II) in tetrahydrofuran at 60; for 24 h;Inert atmosphere;Negishi coupling;

References:

Calimsiz, Selcuk;Sayah, Mahmoud;Mallik, Debasis;Organ, Michael G. [Angewandte Chemie - International Edition,2010,vol. 49,# 11,p. 2014 - 2017] Location in patent:supporting information; experimental part

3034-53-5 Synthesis