ChemicalBook CAS DataBase List 4-BROMO-4'-(DIPHENYLAMINO)BIPHENYL

4-BROMO-4'-(DIPHENYLAMINO)BIPHENYL synthesis

7synthesis methods

Product Name:4-BROMO-4'-(DIPHENYLAMINO)BIPHENYL
CAS Number:202831-65-0
Molecular formula:C24H18BrN
Molecular Weight:400.31

105946-82-5 Synthesis

105946-82-5
238 suppliers
$10.00/10g

122-39-4 Synthesis

122-39-4
334 suppliers
$14.00/5g

202831-65-0
154 suppliers
$19.00/250mg

Yield: 78%

Reaction Conditions:

with dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂;sodium t-butanolate in tolueneInert atmosphere;Reflux;Sonication;

Steps:

1 Example 1: Preparation of Intermediate A-1
Compound I-1 (12.5 g, 73.8 mmol), 4-bromo-4'-iodide (26.5 g, 73.8 mmol) were sequentially added to a round bottom flask.t-BuONa (10.7 g, 111 mmol), Pd(dppf)Cl2.CH2Cl2 (1.2 g, 1.47 mmol), and ultrasonically deoxygenated toluene (1.5 L) were refluxed under nitrogen atmosphere overnight. After cooling the reaction solution, ethyl acetate was used. Ester and water treatment, and the resulting organic layer was dried over MgSO 4Evaporate the solvent under reduced pressureThe crude product of compound II-1 was obtained.With silicone as the stationary phase,Dichloromethane/hexane as eluent,The crude product is subjected to column chromatography.Compound II-1 (23.0 g, 78%) was obtained.

References:

Changchun Hai Purunsi Technology Co., Ltd.;Liu Xiqing;Sun Jing CN107827873, 2018, A Location in patent:Paragraph 0048; 0049; 0050

589-87-7 Synthesis