ChemicalBook CAS DataBase List 4'-CHLORO-BIPHENYL-4-YLAMINE

4'-CHLORO-BIPHENYL-4-YLAMINE synthesis

13synthesis methods

Product Name:4'-CHLORO-BIPHENYL-4-YLAMINE
CAS Number:135-68-2
Molecular formula:C12H10ClN
Molecular Weight:203.67

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Yield: 95%

Reaction Conditions:

with potassium carbonate in water;N,N-dimethyl-formamide at 80; for 1 h;Suzuki-Miyaura Coupling;

Steps:

3. General procedure for Suzuki-Miyaura coupling:
General procedure: To a mixture of aryl halide (1 mmol), arylboronic acid (1.2 mmol), Pd-AcAc-Am-Fe₃O_4/SiO₂ (30 mg ), and K₂CO₃ (3 mmol), DMF: water (8:2, 5 mL) was added and stirred at 80 ^°C under aerobic conditions. After completion of reaction, monitored by TLC, the reaction mixture was cooled. The catalyst was separated by using external magnet. The product was extracted with ethylacetate (2×10 mL) The organic layer was dried with Na₂SO₄and then concentrated on a rotary evaporator afforded corresponding biaryls in excellent yield. The crude products were then purified by column chromatography (2 % ethyl acetate). All synthesized products were confirmed from physical constant IR, ¹H and ¹³C NMR.

References:

Vibhute, Sandip P.;Mhaldar, Pradeep M.;Shejwal, Rajendra V.;Pore, Dattaprasad M. [Tetrahedron Letters,2020,vol. 61,# 11,art. no. 151594] Location in patent:supporting information

1679-18-1 Synthesis