![](/CAS/GIF/4462-55-9.gif)
3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride synthesis
- Product Name:3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride
- CAS Number:4462-55-9
- Molecular formula:C11H6Cl3NO2
- Molecular Weight:290.53
![3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carboxylic acid](/CAS/GIF/3919-76-4.gif)
3919-76-4
127 suppliers
$15.00/1g
![3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride](/CAS/GIF/4462-55-9.gif)
4462-55-9
167 suppliers
$22.00/5g
Yield: 94%
Reaction Conditions:
with thionyl chloride;N,N-dimethyl-formamide at 60;
Steps:
32.3 Step 3, 3-(2,6-dichlorophenyl)-5-methyl-l,2-oxazole-4-carbonyl chloride (23d)
To a 50 mL round-bottom flask was added 3-(2,6-dichlorophenyl)-5-methyl-l,2- oxazole-4-carboxylic acid 23c (600 mg, 2.21 mmol, 1.0 equiv.), thionyi chloride (10 mL), and a catalytic amount of Ν,Ν-dimethylformamide. The resulting mixture was stirred overnight at 60 °C and concentrated in vacuo to give 3-(2,6-dichlorophenyl)-5-methyl-l,2-oxazole-4-carbonyl chloride 23d (600 mg, 94%) as colorless oil.
References:
ARDELYX, INC.;CHAO, Jianhua;JAIN, Rakesh;HU, Lily;LEWIS, Jason Gustaf;BARIBAULT, Helene;CALDWELL, Jeremy WO2018/39384, 2018, A1 Location in patent:Paragraph 00441
![METHYL 3-(2,6-DICHLOROPHENYL)-5-METHYLISOXAZOLE-4-CARBOXYLATE](/CAS/GIF/4402-83-9.gif)
4402-83-9
40 suppliers
$70.00/1 g
![3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride](/CAS/GIF/4462-55-9.gif)
4462-55-9
167 suppliers
$22.00/5g
![2,6-Dichlorobenzaldehyde](/CAS/GIF/83-38-5.gif)
83-38-5
444 suppliers
$6.00/10g
![3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride](/CAS/GIF/4462-55-9.gif)
4462-55-9
167 suppliers
$22.00/5g
![2,6-DICHLORO-N-HYDROXYBENZENECARBOXIMIDOYL CHLORIDE](/CAS/GIF/6579-27-7.gif)
6579-27-7
66 suppliers
$45.00/100mg
![3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride](/CAS/GIF/4462-55-9.gif)
4462-55-9
167 suppliers
$22.00/5g
![2,6-Dichlorobenzaldoxime](/CAS/GIF/25185-95-9.gif)
25185-95-9
121 suppliers
$24.89/5g
![3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride](/CAS/GIF/4462-55-9.gif)
4462-55-9
167 suppliers
$22.00/5g