ChemicalBook CAS DataBase List 3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride

3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride synthesis

6synthesis methods

Product Name:3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride
CAS Number:4462-55-9
Molecular formula:C11H6Cl3NO2
Molecular Weight:290.53

3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carboxylic acid

3919-76-4
129 suppliers
$15.00/1g

3-(2,6-Dichlorophenyl)-5-methylisoxazole-4-carbonyl chloride

4462-55-9
166 suppliers
$22.00/5g

Yield: 94%

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide at 60;

Steps:

32.3 Step 3, 3-(2,6-dichlorophenyl)-5-methyl-l,2-oxazole-4-carbonyl chloride (23d)
To a 50 mL round-bottom flask was added 3-(2,6-dichlorophenyl)-5-methyl-l,2- oxazole-4-carboxylic acid 23c (600 mg, 2.21 mmol, 1.0 equiv.), thionyi chloride (10 mL), and a catalytic amount of Ν,Ν-dimethylformamide. The resulting mixture was stirred overnight at 60 °C and concentrated in vacuo to give 3-(2,6-dichlorophenyl)-5-methyl-l,2-oxazole-4-carbonyl chloride 23d (600 mg, 94%) as colorless oil.

References:

ARDELYX, INC.;CHAO, Jianhua;JAIN, Rakesh;HU, Lily;LEWIS, Jason Gustaf;BARIBAULT, Helene;CALDWELL, Jeremy WO2018/39384, 2018, A1 Location in patent:Paragraph 00441