ChemicalBook CAS DataBase List 5-BROMO-2-(2,2,2-TRIFLUORO-ETHOXY)-PYRIMIDINE

5-BROMO-2-(2,2,2-TRIFLUORO-ETHOXY)-PYRIMIDINE synthesis

5synthesis methods

Product Name:5-BROMO-2-(2,2,2-TRIFLUORO-ETHOXY)-PYRIMIDINE
CAS Number:433683-47-7
Molecular formula:C6H4BrF3N2O
Molecular Weight:257.01

6226-25-1 Synthesis

2,2,2-Trifluoroethyl trifluoromethanesulfonate

6226-25-1
253 suppliers
$11.19/5G

38353-06-9
328 suppliers
$15.00/1g

5-BROMO-2-(2,2,2-TRIFLUORO-ETHOXY)-PYRIMIDINE

433683-47-7
29 suppliers
$50.00/250mg

Yield:433683-47-7 296 mg

Reaction Conditions:

with caesium carbonate in N,N-dimethyl-formamide at 80; for 2 h;

Steps:

3.B B) 5-bromo-2-(2,2,2-trifluoroethoxy)pyrimidine

A mixture of 5-bromopyrimidin-2-ol (500 mg), 2,2,2-trifluoroethyl trifluoromethanesulfonate (796 mg), cesium carbonate (1397 mg) and DMF (5 mL) was stirred at 80° C. for 2 hr.
Water was added to the mixture and the mixture was extracted with ethyl acetate.
The organic layer was separated, washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure.
The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (296 mg).
¹H NMR (300 MHz, CDCl₃) 54.79 (2H, q, J=8.2 Hz), 8.58 (2H, s).

References:

US2020/39957,2020,A1 Location in patent:Paragraph 0641