ChemicalBook CAS DataBase List (alphaR)-alpha-Hydroxy-N-[2-(4-nitrophenyl)ethyl]benzeneacetamide

(alphaR)-alpha-Hydroxy-N-[2-(4-nitrophenyl)ethyl]benzeneacetamide synthesis

4synthesis methods

Product Name:(alphaR)-alpha-Hydroxy-N-[2-(4-nitrophenyl)ethyl]benzeneacetamide
CAS Number:521284-19-5
Molecular formula:C16H16N2O4
Molecular Weight:300.31

611-71-2
620 suppliers
$13.00/5g

29968-78-3 Synthesis

29968-78-3
424 suppliers
$18.00/5g

(alphaR)-alpha-Hydroxy-N-[2-(4-nitrophenyl)ethyl]benzeneacetamide

521284-19-5
154 suppliers
$7.00/250mg

Yield:521284-19-5 93.7%

Reaction Conditions:

with benzotriazol-1-ol;N-[3-(N,N-dimethylamino)-propyl]-N'-ethyl-carbodiimide hydrochloride;triethylamine in N,N-dimethyl-formamide at 20; for 1 h;

Steps:

1 Example 1: Preparation of compound of formula (V)

200 g of the compound of formula (VII) and 286 g of compound of formula (VI) were added to 1.6 kg of N,N-dimethylformamide, and 132 g of triethylamine, 178 g of 1-hydroxybenzotriazole and 264 g of EDCI were added at room temperature. The reaction was stirred at room temperature for 1 h, 1.6 kg of purified water was added, stirred for 2 h for crystallization, filtered and dried to obtain 371 g of the compound of formula (V) with a yield of 93.7%.

References:

CN113880720,2022,A Location in patent:Paragraph 0038-0040

24954-67-4 Synthesis