6-FLUORO-4-HYDROXYQUINOLINE synthesis

2synthesis methods

Product Name:6-FLUORO-4-HYDROXYQUINOLINE
CAS Number:21873-50-7
Molecular formula:C9H6FNO
Molecular Weight:163.15

5-[(4-fluoroanilino)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione

332129-58-5
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21873-50-7
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Yield:21873-50-7 94%

Reaction Conditions:

with dowtherm A for 0.166667 h;Heating / reflux;

Steps:

10.b

Intermediate (10a) (10.9 g, 41 mmol) was slowly added over five minutes to refluxing Dowtherm A (50 ml). After an additional five minutes at reflux, the mixture was allow to cool to room temperature then ether (50 ml) was added. The product was filtered off, thoroughly washed with ether then dried in vacuo to afford the product as a gold coloured solid (16.2 g, 94%). MS (+ve ion electrospray) m/z 164 (MH+).

References:

WO2004/14361,2004,A1 Location in patent:Page/Page column 41

71083-00-6 Synthesis

6-FLUORO-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER

71083-00-6
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21873-50-7
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References

6-FLUORO-4-HYDROXYQUINOLINE Related Search:

6-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 6-FLUORO-4-HYDROXY-2-METHYLQUINOLINE 8-FLUORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 8-FLUORO-4-HYDROXYQUINOLINE 6-FLUORO-4-HYDROXYQUINOLINE 6,8-DIFLUORO-4-HYDROXYQUINOLINE