![](/CAS/20180601/GIF/98165-65-2.gif)
Benzoic acid, 5-(bromomethyl)-2-methoxy-, methyl ester synthesis
- Product Name:Benzoic acid, 5-(bromomethyl)-2-methoxy-, methyl ester
- CAS Number:98165-65-2
- Molecular formula:C10H11BrO3
- Molecular Weight:259.1
![METHYL 2-METHOXY-5-METHYLBENZOATE 97](/CAS/GIF/63113-79-1.gif)
63113-79-1
54 suppliers
$12.00/250mg
![Benzoic acid, 5-(bromomethyl)-2-methoxy-, methyl ester](/CAS/20180601/GIF/98165-65-2.gif)
98165-65-2
34 suppliers
$484.80/250mg
Yield:98165-65-2 94%
Reaction Conditions:
with NBS;azobisisobutyronitrile in Carbon tetrachloride at 78; for 2 h;
Steps:
Methyl 5-(bromomethyl)-2-methoxybenzoate (compound 6):
A mixture of compound 5 (3.04 g, 16.84 mmol), NBS (3.84 g, 21.60 mmol) and AIBN (0.15 g, 0.90 mmol) in CCl4 (90 mL) was refluxed at 78°C for 2 h, then the reaction mixture was filtered and the organic layer was concentrated under vacuum to afford yellowish solid as compound 6 in yield 94% (4.36 g). Compound 6 was directly used for the next step without purification.
References:
Huang, Chaoqun;Shu, Yi;Zhu, Yueyue;Liu, Hongjing;Wang, Xinzhi;Wen, Hongmei;Liu, Jian;Li, Wei [Bioorganic and Medicinal Chemistry,2022,vol. 68,art. no. 116821] Location in patent:supporting information
![Carbon tetrabromide](/CAS/GIF/558-13-4.gif)
558-13-4
251 suppliers
$10.00/1g
![Methyl 5-(hydroxymethyl)-2-methoxybenzoate](/CAS/20200401/GIF/191604-81-6.gif)
191604-81-6
17 suppliers
inquiry
![Benzoic acid, 5-(bromomethyl)-2-methoxy-, methyl ester](/CAS/20180601/GIF/98165-65-2.gif)
98165-65-2
34 suppliers
$484.80/250mg
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
737 suppliers
$9.00/25ml
![2-METHOXY-5-METHYLBENZOIC ACID](/CAS/GIF/25045-36-7.gif)
25045-36-7
106 suppliers
$9.00/250mg
![Benzoic acid, 5-(bromomethyl)-2-methoxy-, methyl ester](/CAS/20180601/GIF/98165-65-2.gif)
98165-65-2
34 suppliers
$484.80/250mg
![2-METHOXY-5-METHYLBENZOIC ACID](/CAS/GIF/25045-36-7.gif)
25045-36-7
106 suppliers
$9.00/250mg
![Benzoic acid, 5-(bromomethyl)-2-methoxy-, methyl ester](/CAS/20180601/GIF/98165-65-2.gif)
98165-65-2
34 suppliers
$484.80/250mg
![Methyl 5-formyl-2-methoxybenzoate](/CAS/GIF/78515-16-9.gif)
78515-16-9
174 suppliers
$50.00/10g
![Benzoic acid, 5-(bromomethyl)-2-methoxy-, methyl ester](/CAS/20180601/GIF/98165-65-2.gif)
98165-65-2
34 suppliers
$484.80/250mg