![](/CAS/GIF/118-42-3.gif)
Hydroxychloroquine synthesis
- Product Name:Hydroxychloroquine
- CAS Number:118-42-3
- Molecular formula:C18H26ClN3O
- Molecular Weight:335.88
Yield:118-42-3 94%
Reaction Conditions:
with KF/Al2O3 in toluene at 110 - 120; for 12 h;Large scale;Reagent/catalyst;Solvent;Temperature;
Steps:
4-6 Example 4: Preparation of hydroxychloroquine free base
1 kg of 4,7-dichloroquinoline, 1 kg of hydroxychloroquine side chain, 1.8 kg of potassium fluoride supported by alumina, dissolved in 5 kg of toluene, heatedTo 110-120 ° C, the reaction was carried out for 12 h, the reaction was complete by TLC, cooled, evaporated toluene, 5 kg of ethyl acetate was added, and heated to reflux.The mixture was filtered while hot, and the filtrate was stirred and cooled for 3 hours, filtered with suction. The filter cake was washed twice with ethyl acetate and dried to give hydroxychloroquine free base.1.6 kg, yield 94%, purity 99.7%,
References:
Nanjing Tianji Coalition Pharmaceutical Technology Co., Ltd.;Qiang Hao;Xu Qiang;Yin Yong CN109456266, 2019, A Location in patent:Paragraph 0003
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