ChemicalBook CAS DataBase List 4,7-Dichloroquinoline

4,7-Dichloroquinoline synthesis

13synthesis methods

Product Name:4,7-Dichloroquinoline
CAS Number:86-98-6
Molecular formula:C9H5Cl2N
Molecular Weight:198.05

4,7-Dichloroquinoline is an important intermediate of antimalarial drugs such as chloroquine phosphate, hydroxychloroquine sulfate, and amodiaquine. It is usually obtained by chlorination and separation of 7-chloro-4-hydroxyquinoline.

86-99-7 Synthesis

86-99-7
180 suppliers
$12.00/5g

86-98-6
502 suppliers
$10.00/10g

Yield:86-98-6 89.5%

Reaction Conditions:

with trichlorophosphateReflux;

Steps:

1-3 Synthesis of 4,7-dichloroquinoline (9) (chloro)

Add 120ml of phosphorus oxychloride to a 250mL three-necked flask, add 40g 4-hydroxy-7-chloroquinoline under stirring, and reflux for 1-2h until the reaction is complete. Cool to spin off the excess phosphorus oxychloride and slowly add the black oil Stir while adding in ice water, then neutralize the sodium bicarbonate aqueous solution to weak alkaline (pH 7-9), filter, wash with water, and crystallize with ethanol to obtain the product with a yield of 89.5%.

References:

CN111362872,2020,A Location in patent:Paragraph 0020; 0027-0028; 0029; 0036-0036; 0038; 0045-0046

23833-97-8 Synthesis