![](/CAS/GIF/124443-68-1.gif)
N-Boc-Piperidine-4-carboxylic acid methyl ester synthesis
- Product Name:N-Boc-Piperidine-4-carboxylic acid methyl ester
- CAS Number:124443-68-1
- Molecular formula:C12H21NO4
- Molecular Weight:243.3
![Methyl isonipecotate](/CAS/GIF/2971-79-1.gif)
2971-79-1
281 suppliers
$10.00/10g
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
821 suppliers
$13.50/25G
![N-Boc-Piperidine-4-carboxylic acid methyl ester](/CAS/GIF/124443-68-1.gif)
124443-68-1
266 suppliers
$6.00/5g
Yield:124443-68-1 98%
Reaction Conditions:
with triethylamine in dichloromethane at 25; for 12 h;Product distribution / selectivity;
Steps:
A.2.1
Synthesis of 9-(Azetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane Trifluoroacetate (A4); Step-1: 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate; To a stirred solution of methyl isonipecotate (127.2 mmol, 1 eq) in dichloromethane (200 ml) were added di-tert-butyldicarbonate (190.8 mmol, 1.5 eq) and triethylamine (254.4 mmol, 2.0 eq). The reaction mixture was stirred for 12 h at 25° C. It was then diluted with dichloromethane (100 ml) and washed with water (50 ml) and brine (50 ml). The organic layer was separated, dried over Na2SO4, concentrated and employed in the next step without further purification. Yield: 98%
References:
US2010/113417,2010,A1 Location in patent:Page/Page column 36
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
739 suppliers
$9.00/25ml
![N-BOC-piperidine-4-carboxylic acid](/CAS/GIF/84358-13-4.gif)
84358-13-4
390 suppliers
$5.00/5g
![N-Boc-Piperidine-4-carboxylic acid methyl ester](/CAS/GIF/124443-68-1.gif)
124443-68-1
266 suppliers
$6.00/5g
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
739 suppliers
$9.00/25ml
![Isonipecotic acid](/CAS/GIF/498-94-2.gif)
498-94-2
492 suppliers
$5.00/10g
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
821 suppliers
$13.50/25G
![N-Boc-Piperidine-4-carboxylic acid methyl ester](/CAS/GIF/124443-68-1.gif)
124443-68-1
266 suppliers
$6.00/5g
![N-BOC-piperidine-4-carboxylic acid](/CAS/GIF/84358-13-4.gif)
84358-13-4
390 suppliers
$5.00/5g
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
341 suppliers
$15.00/10g
![N-Boc-Piperidine-4-carboxylic acid methyl ester](/CAS/GIF/124443-68-1.gif)
124443-68-1
266 suppliers
$6.00/5g
![N-BOC-piperidine-4-carboxylic acid](/CAS/GIF/84358-13-4.gif)
84358-13-4
390 suppliers
$5.00/5g
![(TRIMETHYLSILYL)DIAZOMETHANE](/CAS/GIF/18107-18-1.gif)
18107-18-1
207 suppliers
$33.00/5g
![N-Boc-Piperidine-4-carboxylic acid methyl ester](/CAS/GIF/124443-68-1.gif)
124443-68-1
266 suppliers
$6.00/5g