![](/CAS/GIF/1030377-33-3.gif)
Suvorexant synthesis
- Product Name:Suvorexant
- CAS Number:1030377-33-3
- Molecular formula:C23H23ClN6O2
- Molecular Weight:450.92
![5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid](/CAS/GIF/956317-36-5.gif)
956317-36-5
221 suppliers
$7.00/250mg
![(R)-5-chloro-2-(5-Methyl-1,4-diazepan-1-yl)benzo[d]oxazole](/CAS/GIF/1266975-27-2.gif)
1266975-27-2
72 suppliers
$374.00/250mg
![Suvorexant](/CAS/GIF/1030377-33-3.gif)
1030377-33-3
219 suppliers
$39.00/1mg
Yield:1030377-33-3 97%
Reaction Conditions:
with benzotriazol-1-ol;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;triethylamine in N,N-dimethyl-formamide at 0 - 20;Reagent/catalyst;Solvent;Temperature;
Steps:
1 Example 1:
Diazepane intermediate I (75 mmol) was dissolved in N, N-dimethylformamide (75 ml) followed by reducing body Department of temperature to 0 ~ 5 , was added triazole intermediates II (79mmol),Hydroxybenzotriazole (82.8 mmol), EDCI (82.8 mmol) and triethylamine (188 mmol) were added and the mixture was warmed naturally and stirred at room temperature overnight. Adding 10% citric acid solution, extracting with ethyl acetate, washing the organic layer with 5% sodium carbonate solution, washing with saturated saline solution, drying with anhydrous sodium sulfate, filtering and concentrating to obtain 32.8g of suvresol, yield 97%, Purity: 98.1%; the resulting product was further treated with isopropyl acetate and n-propyl acetate Recrystallization from heptane gave 31.8 g of a white solid in 94% yield
References:
CN106916149,2017,A Location in patent:Paragraph 0018; 0019; 0020; 0021; 0022; 0023; 0024-0045
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![Suvorexant](/CAS/GIF/1030377-33-3.gif)
1030377-33-3
219 suppliers
$39.00/1mg
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![Suvorexant](/CAS/GIF/1030377-33-3.gif)
1030377-33-3
219 suppliers
$39.00/1mg
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$7.00/250mg
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![Suvorexant](/CAS/GIF/1030377-33-3.gif)
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219 suppliers
$39.00/1mg
![(R)-(7-Methyl-1,4-diazepan-1-yl)(5-Methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)Methanone](/CAS/20130318/GIF/CB52599934.gif)
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![Suvorexant](/CAS/GIF/1030377-33-3.gif)
1030377-33-3
219 suppliers
$39.00/1mg