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2-[1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridiniumphosphat

Disopyramid phosphate Struktur
22059-60-5
CAS-Nr.
22059-60-5
Bezeichnung:
2-[1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridiniumphosphat
Englisch Name:
Disopyramid phosphate
Synonyma:
norpace;sc13957;RYTHMODAN;norpace cr;disopyramid phosphate;DISOPYRAMIDE PHOSPHATE;Disopyramide phosphate CRS;DISOPYRAMIDE PHOSPHATE SALT;Disopyramid phosphate USP/EP/BP;Disopyramide Phosphate (200 mg)
CBNumber:
CB7263617
Summenformel:
C21H32N3O5P
Molgewicht:
437.47
MOL-Datei:
22059-60-5.mol
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2-[1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridiniumphosphat Eigenschaften

Schmelzpunkt:
202-204°C
storage temp. 
2-8°C
Löslichkeit
DMSO (Slightly, Heated, Sonicated), Methanol (Slightly), Water (Slightly)
Farbe
White to Off-White
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 22
S-Sätze: 36
WGK Germany  3
RTECS-Nr. UR8440000
HS Code  2933399090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit

2-[1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridiniumphosphat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.

S-Sätze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Verwenden

Cardiac depressant (anti-arrhythmic).

Allgemeine Beschreibung

Disopyramide phosphate, -[2(diisopropylamino)ethyl]- -phenyl-2-pyridineacetamidephosphate (Norpace), is an oral and intravenousclass IA antiarrhythmic agent. It is quite similar to quinidineand procainamide in its electrophysiological properties, inthat it decreases phase 4 diastolic depolarization, decreasesconduction velocity, and has vagolytic properties.31 It is usedclinically in the treatment of refractory, life-threatening ventriculartachyarrhythmias. Oral administration of the drugproduces peak plasma levels within 2 hours. The drug isbound approximately 50% to plasma protein and has a halflifeof 6.7 hours in humans. More than 50% is excretedunchanged in the urine. Therefore, patients with renal insufficiencyshould be monitored carefully for evidence ofoverdose. Disopyramide phosphate commonly exhibits sideeffects of dry mouth, constipation, urinary retention, andother cholinergic blocking actions because of its structuralsimilarity to anticholinergic drugs.

2-[1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridiniumphosphat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Schwefelsure Natriumamid Natriumhydroxid Phenylacetonitril Orthophosphorsure 2-Brompyridin

Downstream Produkte

2-[1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridiniumphosphat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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22059-60-5(2-[1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridiniumphosphat)Verwandte Suche:

Disopyramid 4'-Chloracetanilid Triethylphosphat Polyphosphorsuren, Natriumsalze Trizinkbis(orthophosphat) N,N-Dimethylacetamid Hexadecyldihydrogenphosphat Calcium hydrogenphosphate dihydrate Paracetamol Pyridiniumchlorchromat Acetamid Pentasodium triphosphate hexhydrate Tylosin, Phosphat (Salz) Thioacetamid Diammoniumhydrogenorthophosphat ADENOSINE 5'-TRIPHOSPHATASE Phosphatase, alkalisch Trinatriumorthophosphat
  • DISOPYRAMIDE PHOSPHATE
  • DISOPYRAMIDE PHOSPHATE SALT
  • disopyramid phosphate
  • ALPHA-DIISOPROPYLAMINOETHYL-ALPHA-PHENYLPYRIDINE-2-ACET-AMIDE PHOSPHATE SALT
  • RYTHMODAN
  • norpace cr
  • 2-[1-(ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)]pyridinium phosphate
  • 4-(diisopropylaMino)-2-phenyl-2-(pyridin-2-yl)butanaMide phosphate
  • alpha-(2-(bis(1-methylethyl)amino)ethyl)-alpha-phenyl-2-pyridineacetamid
  • alpha-(2-(diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamidphosphate
  • alpha-(2-diisopropylaminoethyl)-alpha-phenyl-2-pyridineacetamidephosphate
  • norpace
  • sc13957
  • 2-Pyridineacetamide, .alpha.-2-bis(1-methylethyl)aminoethyl-.alpha.-phenyl-, phosphate (1:1)
  • Disopyramide phosphate salt,α-Diisopropylaminoethyl-α-phenylpyridine-2-acetamide
  • Disopyramide Phosphate (200 mg)
  • Disopyramide phosphate CRS
  • Disopyramid phosphate USP/EP/BP
  • Disopyramide Phosphate (1222501)
  • 22059-60-5
  • C21H32N3O5P
  • C21H29N3OH3PO4
  • C21H29N3OH3O4PC21H32N3O5P
  • C21H29N3OH3O4PC21H32N
  • C21H29N3OH3O4P
  • Other Sodium Channel Modulators
  • Sodium Channel Modulators
  • Voltage-gated Ion Channels
  • Ion Channels
  • Monovalent Ion Channels
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
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