Adamantanamine Hydrochloride
- CAS No.
- 665-66-7
- Chemical Name:
- Adamantanamine Hydrochloride
- Synonyms
- AMANTADINE HCL;AMANTADINE HYDROCHLORIDE;1-AMINOADAMANTANE HYDROCHLORIDE;symmetrel;1-ADAMANTANAMINE HCL;Mantadan;ADAMANTANAMINE HYDROCHLORIDE;Amantadine hydrochloride,1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride;Adekin;virasol
- CBNumber:
- CB00124262
- Molecular Formula:
- C10H18ClN
- Molecular Weight:
- 187.71
- MDL Number:
- MFCD00074723
- MOL File:
- 665-66-7.mol
- MSDS File:
- SDS
| Melting point | >300 °C(lit.) |
|---|---|
| Boiling point | 308.63°C (rough estimate) |
| Density | 1.0276 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | H2O: 50 mg/mL |
| form | Fine Crystalline Powder |
| color | White |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| Merck | 14,374 |
| BRN | 4198854 |
| InChIKey | WOLHOYHSEKDWQH-UHFFFAOYSA-N |
| LogP | -1.64 at 23℃ and pH6.3 |
| CAS DataBase Reference | 665-66-7(CAS DataBase Reference) |
| FDA UNII | M6Q1EO9TD0 |
| NCI Dictionary of Cancer Terms | amantadine hydrochloride |
| NCI Drug Dictionary | amantadine hydrochloride |
| Proposition 65 List | Amantadine Hydrochloride |
| EPA Substance Registry System | Amantadine hydrochloride (665-66-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-40-20/21/22 | |||||||||
| Safety Statements | 22-36/37-36-35-20/21 | |||||||||
| RIDADR | UN 1759 8 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | AU4375000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29213000 | |||||||||
| Toxicity | LD50 orally in mice, rats: 700, 1275 mg/kg (Vernier) | |||||||||
| NFPA 704 |
|
Adamantanamine Hydrochloride price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A1260 | Amantadine hydrochloride | 665-66-7 | 5g | $65.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP530 | Amantadine hydrochloride British Pharmacopoeia (BP) Reference Standard | 665-66-7 | 200MG | $257 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.20015 | 1-Adamantaneammonium chloride for synthesis | 665-66-7 | 10g | $66.1 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.20015 | 1-Adamantaneammonium chloride for synthesis | 665-66-7 | 50g | $241 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1018505 | Amantadine hydrochloride United States Pharmacopeia (USP) Reference Standard | 665-66-7 | 200mg | $436 | 2024-03-01 | Buy |
Adamantanamine Hydrochloride Chemical Properties,Uses,Production
Uses
Adamantanamine Hydrochloride is an antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. It is also used an NMDA-receptor antagoinst.
Synthesis
a kind of synthetic method of adamantanamine hydrochloride, comprises the steps:
1. react: 5 parts of (massfraction) sulfuric acid are joined in reaction vessel, with cold salt bath control temperature to-7 DEG C, drip 0.5 part of acetonitrile, again temperature is controlled at-3 DEG C, add 0.01 part of nickel catalyzator, then 1 part of amantadine is divided into two batches joins in above-mentioned mixed solution, after amantadine has added, be warming up to 18 DEG C, be incubated 6.5 hours;
2. be hydrolyzed: separately get a reaction vessel, add 28 parts of water, make its temperature be no more than 0 DEG C with ice bath, drip the liquid of step 1. after insulation, then add 13 parts of methylene dichloride wherein, stir 25 minutes;
3. extract: stopping is stirred and after stratification, the aqueous phase got wherein extracts with 6 parts of methylene dichloride;
4. dissolve: by the methylene dichloride evaporate to dryness after extraction, 7.5 parts of propyl carbinols are added in residue, 1 part of sodium hydroxide is added after stirring and dissolving, be heated to can carry out back flow reaction and react 7.5 hours, add 9.5 parts of water after cooling and stir 25 minutes, stop stirring treating its layering, get organic phase 4.5 parts of water washings once;
5. crystallization: stir above-mentioned organic phase, drips the hydrochloric acid 1.2 parts of 36%, and after crystallization, centrifuging obtains once thick product, once adds 10 parts of methylcarbonates again in thick product and carries out recrystallization, then after centrifugal, obtain the thick product of secondary;
6. wash drying: washed through methylcarbonate by thick for secondary product, after dry at 55 DEG C in vacuum drying oven, after drying finished product Adamantanamine Hydrochloride.
Adamantanamine Hydrochloride Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Qiwei Pharmatech Co.,Ltd | 13282840061 | mw@qwpharmatech.com | China | 109 | 58 |
| Huzhou Chenxi Environmental Protection Technology Co. , Ltd. | +8616762203950 | 1034385273@qq.com | China | 55 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5895 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 | sarah@tnjone.com | China | 1143 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019 +86-15383190639 | admin@86-ss.com | China | 1000 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | bj1@bj-chem.com | China | 299 | 55 |
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- Nov 16，2023
View Lastest Price from Adamantanamine Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-07-01 | Adamantanamine hydrochloride
665-66-7
|
US $100.00 / kg | 1kg | 99% | 1t | Zibo Wei Bin Import & Export Trade Co. Ltd. | |
 |
2023-01-31 | 1-Adamantanamine hydrochloride
665-66-7
|
US $50.00 / KG | 1KG | 99% | 5000KG | Hebei Mojin Biotechnology Co., Ltd | |
 |
2021-04-03 | 1-Adamantanamine hydrochloride
665-66-7
|
US $1.00 / KG | 1KG | 99% | 10 mt | Hebei Guanlang Biotechnology Co., Ltd. |
-
- Adamantanamine hydrochloride
665-66-7
- US $100.00 / kg
- 99%
- Zibo Wei Bin Import & Export Trade Co. Ltd.
-
- 1-Adamantanamine hydrochloride
665-66-7
- US $50.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- 1-Adamantanamine hydrochloride
665-66-7
- US $1.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
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