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Trifluoroacetic Acid Anhydride

Trifluoroacetic Acid Anhydride Structure
Trifluoroacetic Acid Anhydride structure
CAS No.
407-25-0
Chemical Name:
Trifluoroacetic Acid Anhydride
Synonyms
TFAA;trifluoroacetic;2,2,2-Trifluoroacetic anhydride;TRIFLUOROACETIC ACID ANHYDRIDE;TRIFLUORACETIC ANHYDRIDE;Trifluoroacetic anhy;TIFLUOROACETIC ANHYDRIDE;trimethylamine (TMA);uoroacetic anhydride;TRIFLUOROACETO ANHYDRIDE
CBNumber:
CB00124774
Molecular Formula:
C4F6O3
Molecular Weight:
210.03
MDL Number:
MFCD00000416
MOL File:
407-25-0.mol
MSDS File:
SDS
Last updated:2024-11-22 13:52:42
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Trifluoroacetic Acid Anhydride Properties

Melting point -65 °C (lit.)
Boiling point 39.5-40 °C (lit.)
Density 1.511 g/mL at 20 °C (lit.)
vapor pressure 6.28 psi ( 20 °C)
refractive index n20/D 1.3(lit.)
Flash point -26 °C
storage temp. 2-8°C
solubility Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile.
form Liquid
pka 0.43[at 20 ℃]
Specific Gravity 1.487
color Clear
Water Solubility Hydrolysis
Sensitive Moisture Sensitive
BRN 746197
Stability Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents.
LogP 0.79 at 25℃
CAS DataBase Reference 407-25-0(CAS DataBase Reference)
FDA UNII 5ENA87IZHT
NIST Chemistry Reference Acetic acid, trifluoro-, anhydride(407-25-0)
EPA Substance Registry System Acetic acid, trifluoro-, anhydride (407-25-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07
Signal word  Danger
Hazard statements  H314-H332-H412
Precautionary statements  P273-P280-P301+P330+P331-P303+P361+P353-P304+P340+P312-P305+P351+P338+P310
Hazard Codes  C,T
Risk Statements  14-20-35-52/53-34-23/24/25
Safety Statements  26-36/37/39-43-45-61-9-8-28A-27
RIDADR  UN 3265 8/PG 1
WGK Germany  2
RTECS  AJ9800000
F  3-10
Hazard Note  Corrosive/Moisture Sensitive
TSCA  T
HazardClass  8
PackingGroup  I
HS Code  29159080
Toxicity skn-rbt 500 mg/24H SEV 28ZPAK -,91,72
NFPA 704
0
3 1

Trifluoroacetic Acid Anhydride price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.08261 Trifluoroacetic anhydride for synthesis 407-25-0 25mL $43.7 2024-03-01 Buy
Sigma-Aldrich 8.08261 Trifluoroacetic anhydride for synthesis 407-25-0 100mL $114 2024-03-01 Buy
Sigma-Aldrich 106232 Trifluoroacetic anhydride ReagentPlus , ≥99% 407-25-0 10x1g $212 2024-03-01 Buy
Sigma-Aldrich 8.08261 Trifluoroacetic anhydride for synthesis 407-25-0 500mL $456 2024-03-01 Buy
Sigma-Aldrich 106232 Trifluoroacetic anhydride ReagentPlus , ≥99% 407-25-0 3kg $1460 2024-03-01 Buy
Product number Packaging Price Buy
8.08261 25mL $43.7 Buy
8.08261 100mL $114 Buy
106232 10x1g $212 Buy
8.08261 500mL $456 Buy
106232 3kg $1460 Buy

Trifluoroacetic Acid Anhydride Chemical Properties,Uses,Production

Description

Trifluoroacetic acid anhydride (TFAA), a perfluoroacylated acylation reagent, forms stable, volatile derivatives with alcohols, amines, and phenols. 

Chemical Properties

Clear, colorless liquid

Uses

Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.

Uses

Used as analytical reagents, solvents, catalysts, dehydration condensing agent, protection agent of trifluoroacetylation of carboxyl and amino; used as Intermediate of fluorine fine chemicals, pharmaceutical, agrochemical.

Preparation

Trifluoroacetic anhydride is prepared by reaction of trifluoroacetyl chloride with an alkali metal or alkaline-earth metal salt of trifluoroacetic acid at approximately 50° C. 

Safety Profile

A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit

Purification Methods

Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]

Trifluoroacetic Acid Anhydride synthesis

76-05-1
407-25-0
Synthesis of Trifluoroacetic Acid Anhydride from Trifluoroacetic acid

Trifluoroacetic Acid Anhydride Preparation Products And Raw materials

Raw materials

DICHLOROACETIC ANHYDRIDE Trifluoroacetic acid

Preparation Products

1-[4-(TRIFLUOROMETHYL)PYRIMID-2-YL]PIPERAZINE 2-CYANO-4-PYRIDINE CARBOXYLIC ACID 2-Hydroxy-4-(trifluoromethyl)pyrimidine 5-Bromo-2-hydroxymethylpyridine 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile
2-Chloro-4-(trifluoromethyl)pyrimidine [BIS(TRIFLUOROACETOXY)IODO]PENTAFLUOROBENZENE 6-Aminobenzothiazole 2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINIC ACID 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide
(2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamine 2,6-DICHLORO-4-ISOCYANATOPYRIDINE Ethyl 2-(4-hydroxypiperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate
3-(Trifluoromethyl)pyrazole 1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE Chlorfenapyr (2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanol 3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
4-CHLORO-ALPHA-[METHYL(TRIFLUOROACETYL)AMINO]-BENZENEACETIC ACID 2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97% 3-Nitroisonicotinic acid Ethyl 2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine 5-Iodo-2,4-dimethoxypyrimidine N10-(TRIFLUOROACETYL)PTEROIC ACID 3-Amino-4-nitrobenzitrifluoride 2-(TRIFLUOROACETYL)THIOPHENE
2-BROMO-4-(TRIFLUOROMETHYL)PYRIMIDINE 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbaldehyde Epirubicin 2-(Bromomethyl)-6-methylpyridine 5-Bromopyridine-2-carbaldehyde
ETHYL 5-AMINO-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylic acid 2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-amine 3-CHLORO-5-NITROPYRIDINE [Bis(trifluoroacetoxy)iodo]benzene

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Trifluoroacetic Acid Anhydride Suppliers

Global( 547)Suppliers
Supplier Tel Email Country ProdList Advantage
CD Chemical Group Limited
+8615986615575 info@codchem.com China 20342 58
Shaanxi Didu New Materials Co. Ltd
+86-89586680 +86-13289823923 1026@dideu.com China 8670 58
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085 abby@weibangbio.com China 8812 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5893 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18779 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +8618949832763 info@tnjchem.com China 2986 55
Zjartschem 		+86-571 87238903 jocelynpan@zjarts.com CHINA 988 58
Supplier Advantage
CD Chemical Group Limited
58
Shaanxi Didu New Materials Co. Ltd
58
Hebei Weibang Biotechnology Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55
Hefei TNJ Chemical Industry Co.,Ltd. 		55
Zjartschem 		58

Related articles

View Lastest Price from Trifluoroacetic Acid Anhydride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Trifluoroacetic Anhydride pictures 2024-10-11 Trifluoroacetic Anhydride
407-25-0
 US $10.00 / KG 1KG 99.7% 10 ton Hebei Chuanghai Biotechnology Co,.LTD
Trifluoroacetic anhydride pictures 2021-07-13 Trifluoroacetic anhydride
407-25-0
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Trifluoroacetic anhydride pictures 2019-07-06 Trifluoroacetic anhydride
407-25-0
 US $1.00 / KG 1KG 98% 1 Career Henan Chemical Co

Trifluoroacetic anhydride Spectrum

Trifluoroacetic anhydride(407-25-0)MSTrifluoroacetic anhydride(407-25-0)13CNMRTrifluoroacetic anhydride(407-25-0)IR1

407-25-0(Trifluoroacetic Acid Anhydride)Related Search:

Glutaric anhydride Ethyl trifluoroacetate Succinic anhydride Isatoic Anhydride Trifluoromethanesulfonic anhydride
Phthalic anhydride CIS-BUTENEDIOIC ANHYDRIDE Trifluoroacetic acid Sodium trifluoroacetate Potassium trifluoroacetate
Trifluoromethanesulfonic acid tert-butyldimethylsilyl ester Trifluoromethanesulfonic acid Trifluoroacetamide Trifluoroacetophenone Trifluoroacetamidine
Acetic anhydride 2,2,2-TRIFLUOROETHYL METHYL ETHER 2-Fluoroethanol Trifluoroacetic Acid Anhydride

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TRIFLUOROACETO ANHYDRIDE Trifluoroacetic acid anhydride (TFAH) RIFLUOROACETIC ANHYDRIDE Trifluoroacetic anhydride 10g [407-25-0] Trifluoroacetic anhydride, min. 98% trifluoroacetyl 2,2,2-trifluoroacetate Trifluoroacetic anhydride, 99+% 100GR Trifluoroacetic anhydride, 99+% 25GR Trifluoracetic anhydride, min. 98% Bis(2,2,2-trifluoroacetic acid)anhydride Bis(trifluoroacetic acid) anhydride Di(trifluoroacetic)anhydride Trifluoroacetyltrifluoroacetate Trifluoroethanoicanhydride TRIFLUOROACETIC ANHYDRIDE BIS(TRIFLUOROACETIC) ANHYDRIDE Triflyuoroacetic anhydride Aceticacid,trifluoro-,anhydride Anhydrid kyseliny trifluoroctove anhydridkyselinytrifluoroctove Hexafluoroacetic anhydride hexafluoroaceticanhydride Perfluoroacetic anhydride perfluoroaceticanhydride TRIFLUOROACETIC ANHYDRIDE, REAGENTPLUS, >=99% TRIFLUOROACETIC ANHYDRIDE, DERIVATIZA-TI ON REAGENT TRIFLUOROACETIC ANHYDRIDE REAGENTPLUS(& TrifluoroaceticAnhydride/Tfaa/Tfah/Trifluoroaceticanhydride TrifluoroaceticAnhydride/Tfaa Trifluoroacetic anhydride, 99+% Trifluoraceticanhydride,min.98% TRIFLUOROACETICANHYDRIDE,REAGENT Trifluoressigsureanhydrid Perfluoracetic anhydride TRIFLUOROACETIC ANHYDRIDE: 99.5% TRIFLUOROACETIC ANHYDRIDE FOR SYNTHESIS TRIFLUOROACETIC ANHYDRIDE FOR GAS CHROMA Trifluoroacetic anhydride 99% TRIFLUOROACETIC ANHYDRINE TFAH)Trifluoroacetic anhyd 1,1,1,5,5,5-Hexafluoro-3-oxapentan-2,4-dione, Perfluoro(3-oxapentan-2,4-dione), 2,2,2-Trifluoroethanoic anhydride Aceticacid, 2,2,2-trifluoro-, 1,1'-anhydride Three fluorineacetic anhydride trimethylamine (TMA) Trifluoroacetic anhydride ReagentPlus(R), >=99% Trifluoroacetyl 2,2,2-trifluoroacetate (Trifluoroacetic anhydride) Trifluoroacetic anhydride≥ 99% (GC) TFAA Trifluoroacetic acid anhydride trifluoro-aceticacianhydride Trifluoroacetyl anhydride trifluoroacetylanhydride Trifluoroacetic Anhydride > Trifluoroacetic Anhydride (Reagent), Fisher Chemical Trifluoroacetic Anhydride, 99&plus uoroacetic anhydride Trifluoroacetic anhydride 407-25-0 fiona trifluorocytic anhydride fiona TRIFLUOROACETIC ANHYDRIDE, 99%TRIFLUOROACETIC ANHYDRIDE, 99%TRIFLUOROACETIC ANHYDRIDE, 99%TRIFLUOROACETIC ANHYDRIDE, 99%