Progestin
- CAS No.
- 57-83-0
- Chemical Name:
- Progestin
- Synonyms
- Lutein;PROCYANIDINS;Progesteron;Progestrone;Lutin;progestin;Luteine;Prometrium;Pregn-4-ene-3,20-dione;CIDR
- CBNumber:
- CB00128200
- Molecular Formula:
- C21H30O2
- Molecular Weight:
- 314.46
- MDL Number:
- MFCD00003658
- MOL File:
- 57-83-0.mol
- MSDS File:
- SDS
| Melting point | 128-132 °C (lit.) |
|---|---|
| Boiling point | 394.13°C (rough estimate) |
| alpha | 186 º (c=1, ethanol) |
| Density | d23 1.166; d20 1.171 |
| refractive index | 182 ° (C=2, Dioxane) |
| Flash point | 2℃ |
| storage temp. | room temp |
| solubility | H2O: 25 mg/mL, may be clear to slightly hazy |
| form | powder |
| color | Yellow to yellow-brown |
| Water Solubility | <0.1 g/100 mL at 19 ºC |
| Merck | 7773 |
| BRN | 1915950 |
| BCS Class | 4 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | RJKFOVLPORLFTN-LEKSSAKUSA-N |
| LogP | 3.870 |
| CAS DataBase Reference | 57-83-0(CAS DataBase Reference) |
| FDA 21 CFR | 556.540 |
| EWG's Food Scores | 4-7 |
| NCI Dictionary of Cancer Terms | progesterone; progestin |
| FDA UNII | 4G7DS2Q64Y |
| NCI Drug Dictionary | Lutex |
| ATC code | G03DA04 |
| Proposition 65 List | Progesterone |
| NIST Chemistry Reference | Progesterone(57-83-0) |
| EPA Substance Registry System | Progesterone (57-83-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H351-H360FD-H362 | |||||||||
| Precautionary statements | P202-P260-P263-P264-P270-P308+P313 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 40-45-62-36-20/21/22-11 | |||||||||
| Safety Statements | 36/37-45-53-16 | |||||||||
| RIDADR | UN 1648 3 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TW0175000 | |||||||||
| HS Code | 29372390 | |||||||||
| Toxicity | LD50 intraperitoneal in rat: 327mg/kg | |||||||||
| NFPA 704 |
|
Progestin price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P-069 | Progesterone solution 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? | 57-83-0 | 1mL | $142 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP449 | Progesterone British Pharmacopoeia (BP) Reference Standard | 57-83-0 | 50MG | $233 | 2024-03-01 | Buy |
| Sigma-Aldrich | 5341 | Progesterone - CAS 57-83-0 - Calbiochem Steroid hormone secreted by the corpus luteum during the latter half of the menstrual cycle. | 57-83-0 | 25g | $102 | 2024-03-01 | Buy |
| Sigma-Aldrich | 46665 | Progesterone VETRANAL | 57-83-0 | 250mg | $576 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1568007 | Progesterone United States Pharmacopeia (USP) Reference Standard | 57-83-0 | 200mg | $358 | 2024-03-01 | Buy |
Progestin Chemical Properties,Uses,Production
Description
Progestin is the synthetic (human-made) form of progesterone. Progesterone is a hormone that occurs naturally in your body. Some people need treatment with progestin to treat symptoms or conditions.
Physical properties
Progestin is a white powder, melting point 121°C. Stable in air. Insoluble in water.
Uses
Progestin is a synthetic (human-made) form of progesterone that helps treat certain conditions. It is can used to treatment for issues with menstruation, symptoms of menopause, and many others.
Health Hazard
Acute/chronic hazards: Progesterone may be absorbed through the skin.
Side effects
Common side effects of oral Progesterone include: chest pain, chills, cold or flu-like symptoms; cough or hoarseness; fever, and problems with urination. Rare side effects include: clear or bloody discharge; dimpling of the breast skin, lumps in the breast or armpit; persistent crusting or flaking; redness or swelling of the breast; and sores on the breast skin that do not heal. Other side effects that may occur are: abdominal or stomach pain; constipation, difficulty breathing, dizziness, fast, strong, or irregular heartbeat or pulse; headache, measles, indigestion, itching, joint pain, stiffness, or swelling; rash.
Synthesis
Progestin, pregn-4-en-3,20-dione (28.3.1), is made by oxidizing pregnenolon with aluminum isopropylate in the presence of cyclohexanone as a proton acceptor (Oppenauer oxidation). Progestin itself is made by subsequent oxidation and further cleavage of the side chain of stigmasterin, a sterin of plant origin that is isolated from soybeans.
Physiological effects
Progestin is believed to act by inducing decidualization and atrophy of the endometrial tissue within endometriotic implants. Progestin also interfere with follicular growth probably via a central mechanism on the pituitary–hypothalamic unit, but a local ovarian effect is also possible. This will result in decreased estrogen levels.
Toxicity
Low toxicity
Progestin Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | sales@chembj.net | China | 289 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9313 | 58 |
| APOLLO HEALTHCARE RESOURCES | +6596580999 | sales@apollo-healthcare.com.sg | Singapore | 399 | 58 |
| Pharmaceuticals Group Corp., Ltd. | +8613004379774 | wu@jiaerke.com | China | 33 | 58 |
| Senova Technology Co. Ltd. | +86-0755-86703119 +8618503098836 | info@senovatech.com | China | 351 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@sdzhonghuimaterial.com | China | 983 | 58 |
| Shanghai Likang New Materials Co., Limited | +86-16631818819 +86-17736933208 | 3684455296@qq.com | China | 9300 | 58 |
| Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 | info@hyper-chem.com | China | 295 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5976 | 58 |
| Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | Ethan@dornechem.com | China | 3095 | 58 |
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