Z-VAD-FMK | 187389-52-2

Z-VAD-FMK Properties

Melting point	>190°C (dec.)
Boiling point	732.4±60.0 °C(Predicted)
Density	1.214±0.06 g/cm3 (20 ºC 760 Torr)
Flash point	396.7℃
storage temp.	-20°C
solubility	DMSO: 20 mg/mL
form	powder
pka	11.05±0.46(Predicted)
color	white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
InChIKey	MIFGOLAMNLSLGH-QOKNQOGYSA-N
SMILES	C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(OCC1=CC=CC=C1)=O)[C@@H](CC(OC)=O)C(=O)CF
CAS DataBase Reference	187389-52-2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Safety Statements	22-24/25
WGK Germany	3
HS Code	29145090

Z-VAD-FMK price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	V116	Z-VAD-FMK solid	187389-52-2	2mg	$814	2024-03-01	Buy
Sigma-Aldrich	SAB2501669	Anti-CASP3 antibody produced in goat affinity isolated antibody, buffered aqueous solution	187389-52-2	100μg	$568	2024-03-01	Buy
Sigma-Aldrich	627610	Caspase Inhibitor I	187389-52-2	1mg	$318	2024-03-01	Buy
Sigma-Aldrich	627610	Caspase Inhibitor I	187389-52-2	5mg	$662	2024-03-01	Buy
Cayman Chemical	14463	Z-VAD(OMe)-FMK ≥95%	187389-52-2	1mg	$100	2024-03-01	Buy

Product number	Packaging	Price	Buy
V116	2mg	$814	Buy
SAB2501669	100μg	$568	Buy
627610	1mg	$318	Buy
627610	5mg	$662	Buy
14463	1mg	$100	Buy

Z-VAD-FMK Chemical Properties,Uses,Production

Description

Z-VAD-FMK (187389-52-2), cell-permeable, methyl ester form. Potent, irreversible pan-caspase inhibitor. Inhibits caspase activity and apoptosis induction in a variety of cell types (IC50 = 1.5 μM). Active in vivo.

Uses

Z-VAD(OMe)-FMK is a cell-permeable, competitive, and irreversible inhibitor of all caspases. Through this action, it inhibits cleavage of poly(ADP-ribose) polymerase, preventing apoptosis when used at 10-50 μM. It also blocks caspase-mediated apoptosis in vivo. Z-VAD(OMe)-FMK effectively prevents caspase action in inflammasomes.[Cayman Chemical]

Uses

Z-VAD-FMK is a caspase inhibitor that inhibits apoptosis and caspase processing in Jurkat T cells treated with low concentrations of z-FA-CMK.

Definition

ChEBI: Z-Val-Ala-Asp(OMe)-CH2F is a tripeptide consisting of Z-Val-Ala-Asp(OMe) in which the C-terminal OH group has been replaced by a fluoromethyl group. An irreversible pan-caspase inhibitor. It has a role as an apoptosis inhibitor and a protease inhibitor. It is a carbamate ester, a tripeptide and an organofluorine compound.

General Description

A cell-permeable, irreversible, pan-caspase inhibitor. Shown to enhance the freeze-thaw survival of human embryonic stem cells. Inhibits Fas-mediated apoptosis in Jurkat T cells. Also reported to inhibit Peptide: N-glycanse (PNGase) in vitro amd in vivo. When using with a purified recombinant enzyme, pretreatment with an esterase is required.

Biological Activity

Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC 50 = 0.0015-5.8 mM). Active in vivo .

Biochem/physiol Actions

Cell permeable: yes

Enzyme inhibitor

This tripeptide halomethyl ketone (FWfree-acid = 467.49 g/mol; Soluble to 9.35 mg/ml in DMSO; CAS RegistryNumber = 187389-52-2), also known as Z-VAD-FMK and caspase inhibitor VI, is a broad-spectrum caspase inhibitor that blocks caspase-mediated apoptosis. Z-VAD-FMK inhibits caspase processing (IC50 = 0.0015–5.8 mM, depending on enzyme and cell type). The aspartate methyl ester derivative (FW = 467.49 g/mol), also known as caspase inhibitor I, is far more cell-permeable. Target (s) : caspases; caspase-1; caspase-2; caspase-3; caspase-4 ; caspase 5; caspase-6; caspase-7; caspase-8 ; caspase-9; caspase-10.

storage

-20°C

References

1) Slee et al. (1996), Benzyloxycarbonyl-Val-Ala-ASP (OMe) fluoromethylketone (Z-VAD-FMK) inhibits apoptosis by blocking the processing of CPP32; Biochem. J., 315 21 2) Kunstle et al. (1997), ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha; Immunol. Lett., 55 5 3) Garcia-Calvo et al. (1998), Inhibition of human caspases by peptide based and macromolecular inhibitors; J. Biol. Chem., 273 32608

Z-VAD-FMK Preparation Products And Raw materials

Raw materials

Preparation Products

Z-VAD-FMK Suppliers

Global( 211)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19741	58
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9087	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29880	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10311	58
Shanghai Longyu Biotechnology Co., Ltd.	+8619521488211	info@longyupharma.com	China	2541	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	86 18062405514 18062405514	ada@ipurechemical.com	CHINA	3461	58

Supplier	Advantage
BOC Sciences	58
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Shenzhen Nexconn Pharmatechs Ltd	58
Shanghai Longyu Biotechnology Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
TargetMol Chemicals Inc.	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	58

View Lastest Price from Z-VAD-FMK manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-18	Z-VAD(OMe)-FMK 187389-52-2	US $52.00-247.00 / mg		99.41%	10g	TargetMol Chemicals Inc.
2022-10-09	Z-VAD-FMK 187389-52-2	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.
2019-07-06	Z-VAD-FMK 187389-52-2	US $1.00 / KG	1G	98%	100KG	Career Henan Chemical Co

Z-VAD(OMe)-FMK
187389-52-2
US $52.00-247.00 / mg
99.41%
TargetMol Chemicals Inc.

Z-VAD-FMK
187389-52-2
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

Z-VAD-FMK
187389-52-2
US $1.00 / KG
98%
Career Henan Chemical Co

Z-VAD-FMK Spectrum

Z-VAD-FMK(187389-52-2)¹HNMR

187389-52-2(Z-VAD-FMK)Related Search:

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Necrostatin-1 MG-132 LY 294002 HYDROCHLORIDE (2S)-2-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanamido]-3-hydroxypropanoic acid PAC1

AC-DEVD-CHO AC-VDVAD-PNA Z-PHE-DL-ALA-FLUOROMETHYLKETONE Z-VAL-ALA-OH Z-VAL-TRP-OH

CBZ-L-VALINE METHYL ESTER Z-VAL-VAL-ARG-AMC Z-VAL-VAL-OH

1of4

Z-VADC(OME)-FMK methyl (3S)-5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-phenylmethoxycarbonylamino-butanoyl]amino]propanoyl]amino]-4-oxo-pentanoate N-BENZYLOXYCARBONYL-VAL-ALA-ASP FLUOROMETHYL KETONE Z-VAD-FLUOROMETHYLKETONE Z-VAD-FMK Z-VAD-FMK, METHYL ESTER Z-VAD(OME)-FLUOROMETHYLKETONE L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]- N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide z-vad -fmk Anti-CASP3 antibody produced in goat caspase 3, apoptosis-related cysteine peptidase caspase 3, apoptosis-related cysteine protease HGNC:1504 Z-VAD-FMK, >=98% Z-VAD(OME)-FMK Z-VAL-ALA-ASP-FLUOROMETHYLKETONE Z-VAL-ALA-ASP-FMK Z-VAL-ALA-ASP(OCH3)-FLUOROMETHYLKETONE Z-VAL-ALA-ASP(OME)-CH2F Z-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE Z-VAL-ALA-ASP-(OME)-FMK Z-VAL-ALA-DL-ASP-FLUOROMETHYLKETONE Z-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONE Z-VA(OME)D-FMK N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone BENZYLOXYCARBONYL-VAL-ALA-ASP(OME)-FLUOROMETHYLKETONE CARBOBENZOXY-VALYL-ALANYL-ASPARTYL-[O-METHYL]-FLUOROMETHYLKETONE CASPASE-1, INHIBITOR CASPASE-1 INHIBITOR VI (FLUOROMETHYLKETONE) CASPASE INHIBITOR I CASPASE INHIBITOR VI Z-VAD-FMK, Non-methylated PN: WO2005039629 PAGE: 18 claimed protein Z-VAD-FMK (Cell perMeable) 3: PN: WO0158526 SEQID: 3 claimed sequence N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide Z-VAD-FMK, 98%, an irreversible pan-caspase inhibitor Z-VAD(OME)-FMK;Z-VAL-ALA-ASP(OME)-FMK Z-VAL-ALA-DL-ASP(OME)-FLUOROMETHYLKETONEZ-Val-Ala-DL-Asp-fluoroMethylketone CS-2005 CS-1507 Z-VAD-FMK (Z-Val-Ala-Asp(OMe)-FMK) Methyl (S)-3-[(S)-2-[(S)-2-(Cbz-amino)-3-methylbutanamido]propanamido]-5-fluoro-4-oxopentanoate (5S,8S,11S)-Methyl 11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate Z-VAD-FMK USP/EP/BP Caspase 3/7 Activity Assay Kit Methyl (5S,8S,11S)-11-(2-fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oate Inhibitor,ZVAD(OMe)FMK,inhibit,Caspase,Z VAD(OMe) FMK Z-Val-Ala-Dl-Asp(Ome)-FMK 187389-52-2 67465-36-3 C22H30FN3O7 C21H28N3O7F C22H30N3O7F BioChemical Apoptosis and Cell Cycle Cell Biology Cell Signaling and Neuroscience