ChemicalBook >> CAS DataBase List >>N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine structure

CAS No.: 315703-52-7

Chemical Name:: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine

Synonyms: JK 184;CS-2369;JK184 (JK-184;JK184, 10 mM in DMSO;Hh Signaling Antagonist VII;Hh Signaling Antagonist VII, JK184;JK 184, Hedgehog signaling inhibitor;JK 184;JK-184;HH SIGNALING ANTAGONIST VII;JK-184,inhibit,JK 184,JK184,Inhibitor,Hedgehog;Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem

CBNumber:: CB02485085

Molecular Formula:: C19H18N4OS

Molecular Weight:: 350.44

MDL Number:: MFCD01044465

MOL File:: 315703-52-7.mol

MSDS File:: SDS

Last updated:2025-01-27 09:38:02

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N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Properties

storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO: ≥20mg/mL
form	powder
color	off-white to light brown
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H318

Precautionary statements

P280-P305+P351+P338

Hazard Codes

Risk Statements

22-41

Safety Statements

26-36

WGK Germany

NFPA 704

	0
3		0

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	373385	Hh Signaling Antagonist VII, JK184	315703-52-7	5mg	$140	2023-01-07	Buy
Cayman Chemical	15265	JK 184 ≥99%	315703-52-7	1mg	$32	2024-03-01	Buy
Cayman Chemical	15265	JK 184 ≥99%	315703-52-7	5mg	$62	2024-03-01	Buy
Sigma-Aldrich	J4205	JK184 ≥98% (HPLC), powder	315703-52-7	25mg	$314	2022-05-15	Buy
Cayman Chemical	15265	JK 184 ≥99%	315703-52-7	10mg	$109	2024-03-01	Buy

Product number	Packaging	Price	Buy
373385	5mg	$140	Buy
15265	1mg	$32	Buy
15265	5mg	$62	Buy
J4205	25mg	$314	Buy
15265	10mg	$109	Buy

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Chemical Properties,Uses,Production

Uses

JK 184 is a small molecule antagonist of the Hedgehog (Hh) signaling pathway.

Uses

JK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function. JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).[Cayman Chemical]

Biological Activity

Potent downstream hedgehog (Hh) signaling inhibitor that prevents Gli-dependent transcriptional activity (IC 50 = 30 nM). Exhibits antiproliferative activity in a range of cancer cell lines (GI 50 = 3 - 21 nM) and in human xenografts in vivo . Inhibits alcohol dehydrogenase 7 (Adh7) (IC 50 = 210 nM) and acts as a microtubule depolymerizing agent in vitro .

storage

+4°C

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Preparation Products And Raw materials

Raw materials

Preparation Products

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Suppliers

Global( 91)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32965	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49476	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29809	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58

View Lastest Price from N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	JK184 315703-52-7	US $48.00-157.00 / mg		99.89%	10g	TargetMol Chemicals Inc.
	2019-12-26	N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine 315703-52-7	US $1.00 / KG	1KG	97%-99.9%	100kg	Career Henan Chemical Co

JK184
315703-52-7
US $48.00-157.00 / mg
99.89%
TargetMol Chemicals Inc.

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
315703-52-7
US $1.00 / KG
97%-99.9%
Career Henan Chemical Co

315703-52-7(N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine)Related Search:

N-Methylformamide FORMANILIDE 4-Aminodiphenylamine

N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine Hh Signaling Antagonist VII, JK184 JK 184 N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine 2-ThiazolaMine, N-(4-ethoxyphenyl)-4-(2-MethyliMidazo[1,2-a]pyridin-3-yl)- Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem CS-2369 JK184 (JK-184 Hh Signaling Antagonist VII JK 184;JK-184;HH SIGNALING ANTAGONIST VII JK-184,inhibit,JK 184,JK184,Inhibitor,Hedgehog JK 184, Hedgehog signaling inhibitor JK184, 10 mM in DMSO 315703-52-7