POMALIDOMIDE-PEG1-CO2H
- CAS No.
- 2139348-60-8
- Chemical Name:
- POMALIDOMIDE-PEG1-CO2H
- Synonyms
- 3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)propanoic acid;Poma-PEG1-COOH;POMALIDOMIDE-PEG1-CO2H;Pomalidomide-PEG1-COOH;Pomalidomide-PEG1-C2-COOH;Pomalidomide 4'-PEG1-acid;Thalidomide-4-NH-PEG1-COOH;Thalidomide-NH-PEG1-C2-COOH;Pomalidomide-PEG1-CO2H >=95%;Thalidomide-4-NH-PEG1-C2-COOH
- CBNumber:
- CB14743861
- Molecular Formula:
- C18H19N3O7
- Molecular Weight:
- 389.36
- MDL Number:
- MFCD32063496
- MOL File:
- 2139348-60-8.mol
- MSDS File:
- SDS
POMALIDOMIDE-PEG1-CO2H Chemical Properties,Uses,Production
Uses
Protein degrader builiding block Pomalidomide-PEG1-CO2H enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
storage
Store at -20°C
POMALIDOMIDE-PEG1-CO2H Preparation Products And Raw materials
Raw materials
Preparation Products
POMALIDOMIDE-PEG1-CO2H Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
Zhengzhou Lingzhiyue Technology Co., Ltd | +86-0371-55074660 +86-13783527580 | Lingzhiyue@aliyun.com | China | 3152 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 6000 | 58 |
Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2996 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39010 | 58 |
Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 7182 | 65 |
View Lastest Price from POMALIDOMIDE-PEG1-CO2H manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-02 | Pomalidomide-PEG1-COOH
2139348-60-8
|
US $0.00 / mg | 250mg | >99.00% | 250mg | Xian confluore Biological Technology Co., Ltd. |
- Pomalidomide-PEG1-COOH
2139348-60-8
- US $0.00 / mg
- >99.00%
- Xian confluore Biological Technology Co., Ltd.
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