ml390
- CAS No.
- 2029049-79-2
- Chemical Name:
- ml390
- Synonyms
- ml390;(R)-N-(3-Oxo-3-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)propyl)-4-(trifluoromethoxy)benzamide;Benzamide, N-[3-oxo-3-[[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]propyl]-4-(trifluoromethoxy)-;ER-HoxA9,Dihydroorotate Dehydrogenase,inhibit,AML,ML 390,differentiatio,U937,DHODH,ML390,myeloid,ML-390,Inhibitor,THP1
- CBNumber:
- CB43145908
- Molecular Formula:
- C21H21F3N2O3
- Molecular Weight:
- 406.4
- MDL Number:
- MOL File:
- 2029049-79-2.mol
ml390 price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21395 | ML-390 ≥98% | 2029049-79-2 | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 21395 | ML-390 ≥98% | 2029049-79-2 | 10mg | $87 | 2024-03-01 | Buy |
| Cayman Chemical | 21395 | ML-390 ≥98% | 2029049-79-2 | 25mg | $190 | 2024-03-01 | Buy |
| Cayman Chemical | 21395 | ML-390 ≥98% | 2029049-79-2 | 50mg | $286 | 2024-03-01 | Buy |
| ChemScene | CS-5978 | ML390 98.77% | 2029049-79-2 | 100mg | $410 | 2021-12-16 | Buy |
ml390 Chemical Properties,Uses,Production
Description
ML-390 is an inhibitor of dihydroorotate dehydrogenase (DHODH), the enzyme that converts dihydroorotate to orotate during de novo pyrimidine synthesis. In acute myeloid leukemia, leukemic myeloblast development is halted at an immature stage leading to perpetual self-renewal rather than differentiation. ML-390 induces differentiation in the acute myeloid leukemia cell lines U937 (murine) and THP-1 (human) cell lines with an EC50 value of approximately 2 μM.
in vitro
in the screening study, ml390 was identified as the most potent compound against the engineered erhox-gfp cell line. moreover, the addition of uridine to the cell culture media could abrogate the differentiation effects of ml390, demonstrating further evidences that ml390’ effects were due to their inhibition of dhodh-catalyzed pyrimidine synthesis. in addition, ml390 was found to be not able to inhibit dhodh in the p. falciparum parasite, which is the causative agent of malaria. furthermore, the x-ray structure indicated that the binding of ml390 to the enzyme might be increased by modifying ml390 with a ring in its central portion to lock the molecule into its binding conformation with the amide substituents [1].
IC 50
0.56 μm
References
[1] timothy a lewis et al. development of ml390: a human dhodh inhibitor that induces differentiation in acute myeloid leukemia. acs med chem lett 2016 dec 28;7(12):1112-1117. epub 2016 sep 28.
ml390 Preparation Products And Raw materials
Raw materials
Preparation Products
ml390 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 478 | 55 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 7268 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29785 | 68 |
| Twochem Co.Ltd. | 021-58111628 15800915896 | sales@twochem.com | China | 1788 | 58 |
| Guangzhou Tomums Life Science Co., Ltd. | 020-31155029 18902330969 | sales@tomums.cn | China | 4696 | 58 |
