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4-Iodo-2-(trifluoromethyl)pyridine

4-Iodo-2-(trifluoromethyl)pyridine structure

CAS No.: 590371-73-6

Chemical Name:: 4-Iodo-2-(trifluoromethyl)pyridine

Synonyms: 4-lodo-2-(trifluoromethyl)pyridine;2-(trifluoroMethyl)-4-iodopyridine;4-IODO-2-(TRIFLUOROMETHYL)PYRIDINE;4-IODE-2-(TRIFLUOROMETHYL)PYRIDINE;Pyridine,4-iodo-2-(trifluoromethyl)-;4-Iodo-2-(trifluoromethyl)pyridine97%;4-Iodo-2-(trifluoromethyl)pyridine 97%;4-Iodo-2-(trifluoromethyl)pyridine ISO 9001：2015 REACH;4-Iode-2-(trifluoromethyl)pyridine (not restricted/prohibited)(lab chemical)

CBNumber:: CB4722177

Molecular Formula:: C6H3F3IN

Molecular Weight:: 272.99

MDL Number:: MFCD08234939

MOL File:: 590371-73-6.mol

MSDS File:: SDS

Last updated:2023-10-17 11:53:47

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4-Iodo-2-(trifluoromethyl)pyridine Properties

Melting point	24-26 °C
Boiling point	206.2±35.0 °C(Predicted)
Density	1.974g/ml
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	liquid
pka	-0.82±0.20(Predicted)
color	Clear, colourless to pale yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H227-H315-H319-H335
Precautionary statements	P305+P351+P338
Hazard Codes	Xi
HazardClass	IRRITANT
HS Code	2933399990

4-Iodo-2-(trifluoromethyl)pyridine price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	I724775	4-Iodo-2-(trifluoromethyl)pyridine	590371-73-6	5G	$295	2021-12-16	Buy
SynQuest Laboratories	3H32-K-42	4-Iodo-2-(trifluoromethyl)pyridine 95%	590371-73-6	5G	$341	2021-12-16	Buy
Apolloscientific	PC8981	4-Iodo-2-(trifluoromethyl)pyridine 95%	590371-73-6	5g	$213	2021-12-16	Buy
Apolloscientific	PC8981	4-Iodo-2-(trifluoromethyl)pyridine 95%	590371-73-6	250mg	$20	2021-12-16	Buy
SynQuest Laboratories	3H32-K-42	4-Iodo-2-(trifluoromethyl)pyridine 95%	590371-73-6	250mg	$32	2021-12-16	Buy

Product number	Packaging	Price	Buy
I724775	5G	$295	Buy
3H32-K-42	5G	$341	Buy
PC8981	5g	$213	Buy
PC8981	250mg	$20	Buy
3H32-K-42	250mg	$32	Buy

4-Iodo-2-(trifluoromethyl)pyridine Chemical Properties,Uses,Production

Uses

4-Iodo-2-(trifluoromethyl)pyridine is used as a reagent in the synthesis of aminoisoindoles as β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors which exhibit in vivo brain reduction of β-amyloid peptides.

Reactivity Profile

4-Iodo-2-(trifluoromethyl)pyridine could be cleanly deprotonated by LIDA in tetrahydrofuran at –75 °C[1]. Trapping of the organometallic intermediates with dry ice followed by neutralization gave the 4-iodo-2-(trifluoromethyl)pyridine-3-carboxylic acid (16, 31%). a: LIDA in THF at –75 °C for 2 h; b: (1.) Excess solid carbon dioxide, (2.) Hydrochloric acid.

References

[1] Schlosser M, et al. Further Metalations and Functionalizations of Chloro-, Bromo- and Iodo(trifluoromethyl)pyridines. Synthesis, 2004; 10: 1619-1624.

4-Iodo-2-(trifluoromethyl)pyridine synthesis

Synthesis of 4-Iodo-2-(trifluoromethyl)pyridine from 4-Amino-2-trifluoromethylpyridine

4-Iodo-2-(trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

2-(Trifluoromethyl)isonicotinic acid 2-(Trifluoromethyl)pyridine-4-boronic acid

4-Iodo-2-(trifluoromethyl)pyridine Suppliers

Global( 111)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boc Chemical Co., Ltd.	021-34975602; +8618721111801	shangli@bocchem.com	China	138	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29857	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49732	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10035	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58

Supplier	Advantage
Shanghai Boc Chemical Co., Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58
Antai Fine Chemical Technology Co.,Limited	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58

View Lastest Price from 4-Iodo-2-(trifluoromethyl)pyridine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-10-28	4-Iodo-2-(trifluoromethyl)pyridine 590371-73-6	US $1.10 / g	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
	2019-09-05	4-Iodo-2-(trifluoromethyl)pyridine 590371-73-6	US $6.00 / KG	1KG	95%-98%	100	Career Henan Chemical Co

4-Iodo-2-(trifluoromethyl)pyridine
590371-73-6
US $1.10 / g
99.00%
Dideu Industries Group Limited

4-Iodo-2-(trifluoromethyl)pyridine
590371-73-6
US $6.00 / KG
95%-98%
Career Henan Chemical Co

4-Iodo-2-(trifluoromethyl)pyridine Spectrum

4-Iodo-2-(trifluoromethyl)pyridine(590371-73-6)¹HNMR

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4-Iodo-2-(trifluoromethyl)pyridine97% 4-Iodo-2-(trifluoromethyl)pyridine 97% 4-IODO-2-(TRIFLUOROMETHYL)PYRIDINE 2-(trifluoroMethyl)-4-iodopyridine Pyridine,4-iodo-2-(trifluoromethyl)- 4-IODE-2-(TRIFLUOROMETHYL)PYRIDINE 4-Iodo-2-(trifluoromethyl)pyridine ISO 9001：2015 REACH 4-Iode-2-(trifluoromethyl)pyridine (not restricted/prohibited)(lab chemical) 4-lodo-2-(trifluoromethyl)pyridine 590371-73-6 1250277-69-2 Pyridine Pyridine series Halides Pyridines Heterocycle Fluorine series