Indole-3-carbinol
- CAS No.
- 700-06-1
- Chemical Name:
- Indole-3-carbinol
- Synonyms
- I3C;Indol-3-carbinol;3-INDOLEMETHANOL;INDOLE-3-METHANOL;3-indolylcarbinol;INDOLE-3-CARBINOLE;Indinol;e-3-carbinoL;ndolemethanol;AKOS NCG1-0099
- CBNumber:
- CB7295605
- Molecular Formula:
- C9H9NO
- Molecular Weight:
- 147.17
- MDL Number:
- MFCD02683932
- MOL File:
- 700-06-1.mol
- MSDS File:
- SDS
| Melting point | 96-99 °C (lit.) |
|---|---|
| Boiling point | 267.28°C (rough estimate) |
| Density | 1.1135 (rough estimate) |
| refractive index | 1.5670 (estimate) |
| storage temp. | 2-8°C |
| solubility | soluble in Methanol |
| form | Crystalline Powder or Flakes |
| pka | 15.10±0.10(Predicted) |
| color | Off-white to yellow-orange |
| BRN | 121323 |
| Stability | 2-80C |
| InChI | InChI=1S/C9H9NO/c11-6-7-5-10-9-4-2-1-3-8(7)9/h1-5,10-11H,6H2 |
| InChIKey | IVYPNXXAYMYVSP-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2)C(CO)=C1 |
| LogP | 1.366 (est) |
| CAS DataBase Reference | 700-06-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | indole-3-carbinol |
| FDA UNII | C11E72455F |
| NCI Drug Dictionary | indole-3-carbinol |
Indole-3-carbinol price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I7256 | Indole-3-carbinol | 700-06-1 | 1g | $68.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | I7256 | Indole-3-carbinol | 700-06-1 | 5g | $93.4 | 2024-03-01 | Buy |
| TCI Chemical | I0496 | 3-Indolemethanol >98.0%(HPLC)(N) | 700-06-1 | 5g | $40 | 2024-03-01 | Buy |
| TCI Chemical | I0496 | 3-Indolemethanol >98.0%(HPLC)(N) | 700-06-1 | 25g | $195 | 2024-03-01 | Buy |
| Alfa Aesar | L15762 | 3-Indolemethanol, 97% | 700-06-1 | 1g | $22.65 | 2024-03-01 | Buy |
Indole-3-carbinol Chemical Properties,Uses,Production
Chemical Properties
Indole-3-carbinol is an off-white powder. It is soluble in organic solvents such as benzene, ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of Indole-3-carbinol in ethanol and DMF is approximately 10 mg/ml and approximately 3 mg/ml in DMSO. Indole-3-carbinol is an unstable compound that undergoes rapid oligomerization in acid pH environments, like the stomach.
Occurrence
Indole-3-carbinol is produced by members of the family Cruciferae, and particularly members of the genus Brassica (e.g., cabbage, radishes, cauliflower, broccoli, Brussels sprouts, and daikon).
Uses
Indole-3-carbinol has been used for encapsulation with poly-lactic-co-glycolic acid (PLGA), to study its in-vitro anti-cancerogenic effects on breast adenocarcinoma epithelial (MCF7), colon adenocarcinoma epithelial (Caco2), prostate carcinoma epithelial (PC3) cells. It has also been used as a cytochrome P4501A (CYP1A) inducer.
Preparation
Using indole, phosphorus oxychloride and N,N-dimethylformamide as raw materials, indole-3-carbaldehyde was synthesized by Vilsmeier-Haack reaction with a yield of 87.1%.
Definition
ChEBI: Indole-3-carbinol is an indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Application
Indole-3-carbinol (I3C) is a secondary plant metabolite of 3-methylindole produced in Brassica family vegetables. It is an inhibitor of Amyloid-beta deposition and Inhibits cancinogenesis at the initiation stage. Indole-3-carbinol is used in cancer prevention, specifically for breast, cervical and colon cancers. It has also been widely used to address lupus.
Synthesis Reference(s)
Canadian Journal of Chemistry, 31, p. 775, 1953 DOI: 10.1139/v53-106
The Journal of Organic Chemistry, 61, p. 1493, 1996 DOI: 10.1021/jo951219c
General Description
Indole-3-carbinol is a novel secondary plant metabolite produced in cruciferous vegetables, such as cabbage, cauliflower and brussels sprouts.
Biochem/physiol Actions
Inhibits cancinogenesis at the initiation stage. Has be shown to inhibit carcinogenesis in several animal species, but it enhances tumor incidence if administered at a post-initiation stage. Found in cruciferous vegetables.
Anticancer Research
I3C is a bioactive compound majorly found in Brassica vegetables including broccoli,cauliflower, and collard greens. I3C and its derivative diindolylmethane (DIM)have been investigated for cancer prevention and treatment of breast, prostate, andovarian cancers. I3C partially modulates the tyrosine kinase/PI3K/Akt signalingpathway which leads to the prevention of lung adenocarcinoma which is induced byusing tobacco carcinogen in A/J mice. DIM transduces signaling via aryl hydrocarbon(Ah) receptor, NF-κB/Wnt/Akt/mTOR signaling pathways, cell cycle arrest,modulated cytochrome P450 enzymes, and altered angiogenetic and invasive,metastatic, and epigenetic behavior of cancer cells. Combination of DIM and I3Cinduces Nrf2-mediated phase II drug metabolizing genes (GSTm2, UGT1A1, andNQO1) and antioxidant genes (HO-1, SOD-1) (Weng et al. 2008; 2012).
Indole-3-carbinol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Qinmu Fine Chemical Co.,Ltd. | +8618660799346 | sales@qinmuchem.com | China | 1009 | 58 |
| Suzhou Yuanrui Bio-Tech Co., Ltd | +86-18106132862 +86-18106132862 | sales02@yuanruibio.com | China | 285 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8811 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3882 | 58 |
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 | sales06@tgybio.com | China | 902 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5893 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18153 | 58 |
| Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 3010 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 615 | 58 |
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View Lastest Price from Indole-3-carbinol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-25 | Indole-3-carbinol
700-06-1
|
US $0.00 / KG | 1KG | 99% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2024-11-25 | Indole-3-carbinol
700-06-1
|
US $0.00 / Kg/Drum | 1KG | 99% | 200mt | Jinan Finer Chemical Co., Ltd | |
 |
2024-11-25 | Indole-3-carbinol
700-06-1
|
US $0.00-0.00 / kg | 1kg | 99% | 2000kg | Jinan Jianfeng Chemical Co., Ltd |
-
- Indole-3-carbinol
700-06-1
- US $0.00 / KG
- 99% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Indole-3-carbinol
700-06-1
- US $0.00 / Kg/Drum
- 99%
- Jinan Finer Chemical Co., Ltd
-
- Indole-3-carbinol
700-06-1
- US $0.00-0.00 / kg
- 99%
- Jinan Jianfeng Chemical Co., Ltd