ML291
- CAS No.
- 1523437-16-2
- Chemical Name:
- ML291
- Synonyms
- ML291;ML291 >=98% (HPLC);2-Furancarboxamide, N-[4-[(4-chloro-1-piperidinyl)sulfonyl]phenyl]-5-nitro-
- CBNumber:
- CB83134603
- Molecular Formula:
- C16H16ClN3O6S
- Molecular Weight:
- 413.83
- MDL Number:
- MFCD28016591
- MOL File:
- 1523437-16-2.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315-H335 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| NFPA 704 |
|
ML291 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19831 | ML-291 ≥98% | 1523437-16-2 | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 19831 | ML-291 ≥98% | 1523437-16-2 | 5mg | $106 | 2024-03-01 | Buy |
| Cayman Chemical | 19831 | ML-291 ≥98% | 1523437-16-2 | 10mg | $150 | 2024-03-01 | Buy |
| Cayman Chemical | 19831 | ML-291 ≥98% | 1523437-16-2 | 25mg | $356 | 2024-03-01 | Buy |
| AK Scientific | 1360DJ | N-[4-(4-Chloropiperidin-1-yl)sulfonylphenyl]-5-nitrofuran-2-carboxamide | 1523437-16-2 | 25mg | $495 | 2021-12-16 | Buy |
ML291 Chemical Properties,Uses,Production
Biological Activity
ml-291 is an apoptosis inducer.apoptosis, a process of programmed cell death, occurs in multi-cellular organisms. biochemical events result in characteristic cell changes (morphology) and death. these changes include cell shrinkage, nuclear fragmentation, blebbing, chromatin condensation, chromosomal dna fragmentation, as well as global mrna decay.
in vitro
ml-291 was identified as a novel activator of the apoptotic arm of the unfolded protein response (upr), but not the adaptive arm. specifically, ml-291 could activate signaling via perk/eif2α/chop with ec50 value of 762 nm but not through ire1/xbp1. moreover, ml-291 induced apoptosis in mouse embryonic fibroblasts overexpressing chop, but not in wild-type or chop knockout cells. ml-291 showed minimal activity against a panel of 67 receptors, ion channels, as well as transporters, with the exception of the dopamine transporter with 68% inhibition. in addition, ml-291 showed greater cytotoxicity than average antitumor cell cytotoxicity against colon, melanoma, and renal cancer cell lines in an nci-60 panel [1].
References
[1] flaherty, d. p.,golden, j.e.,liu, c., et al. selective small molecule activator of the apoptotic arm of the upr. probe reports from the nih molecular libraries program (2012).
ML291 Preparation Products And Raw materials
Raw materials
Preparation Products
ML291 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3501 | 55 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 2717893647 14768611851 | 486064515@qq.com | China | 1356 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5141 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9180 | 58 |
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