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palovarotene

palovarotene Structure
palovarotene structure
CAS No.
410528-02-8
Chemical Name:
palovarotene
Synonyms
R 667;Ro 3300074;palovarotene;Unii-28K6I5m16g;R 667;RO 3300074;Ro 3300074|||R 667;Palovarotene(R 667);R667;R 667;R667;RO-3300074;RO 3300074;RO3300074;4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid;(E)-4-(2-(3-((1H-pyrazol-1-yl)Methyl)-5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid
CBNumber:
CB91518527
Molecular Formula:
C27H30N2O2
Molecular Weight:
414.54
MDL Number:
MFCD10565968
MOL File:
410528-02-8.mol
MSDS File:
SDS
Last updated:2024-11-12 15:22:20
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palovarotene Properties

Melting point 249-252°C
Boiling point 592.3±50.0 °C(Predicted)
Density 1.11
storage temp. Refrigerator
solubility DMSO (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated)
pka 4.26±0.10(Predicted)
form Solid
color White to Off-White
FDA UNII 28K6I5M16G
ATC code M09AX11

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

palovarotene price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 28460 Palovarotene 410528-02-8 5mg $81 2024-03-01 Buy
Cayman Chemical 28460 Palovarotene 410528-02-8 25mg $336 2024-03-01 Buy
Cayman Chemical 28460 Palovarotene 410528-02-8 10mg $152 2024-03-01 Buy
TRC P165900 Palovarotene 410528-02-8 100mg $1455 2021-12-16 Buy
ChemScene CS-2031 Palovarotene 99.49% 410528-02-8 100mg $1600 2021-12-16 Buy
Product number Packaging Price Buy
28460 5mg $81 Buy
28460 25mg $336 Buy
28460 10mg $152 Buy
P165900 100mg $1455 Buy
CS-2031 100mg $1600 Buy

palovarotene Chemical Properties,Uses,Production

Description

Palovarotene an orally bioavailable retinoic acid receptor γ (RARγ) agonist. It increases retinoic acid response element (RARE) activity and decreases NF-κB activity induced by IL-1β in primary mouse stromal cells in reporter assays when used at a concentration of 60 nM. Palovarotene (10 nM) inhibits activin A-induced chondrogenic and osteogenic differentiation of mouse fibro/adipogenic progenitors (FAPs) expressing a mutated form of human activin A receptor type I (ACVR1R206H). It inhibits heterotopic ossification and preserves limb movement and growth in a ACVR1R206H fibrodysplasia ossificans progressiva (FOP) mouse model. Palovarotene (1 mg/kg per day for 14 days) decreases heterotopic ossification by 50 to 60% in a rat model of traumatic blast injury.

Uses

Palovarotene, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema.

Definition

ChEBI: Palovarotene is a stilbenoid.

palovarotene Preparation Products And Raw materials

Raw materials

Preparation Products

palovarotene Suppliers

Global( 109)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32951 60
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29814 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32077 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15356 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com China 52849 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
AFINE CHEMICALS LIMITED 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Nanjing Doge Biomedical Technology Co., Ltd 		58

View Lastest Price from palovarotene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
palovarotene pictures 2024-11-12 palovarotene
410528-02-8
 US $33.00-113.00 / mg 98.05% 10g TargetMol Chemicals Inc.
Palovarotene pictures 2020-01-13 Palovarotene
410528-02-8
 US $1.00 / g 1g 99% 1ton Career Henan Chemical Co
  • palovarotene pictures
  • palovarotene
    410528-02-8
  • US $33.00-113.00 / mg
  • 98.05%
  • TargetMol Chemicals Inc.
  • Palovarotene pictures
  • Palovarotene
    410528-02-8
  • US $1.00 / g
  • 99%
  • Career Henan Chemical Co

palovarotene Spectrum

palovarotene(410528-02-8)1HNMR

410528-02-8(palovarotene)Related Search:

ANTI-ESTROGEN RECEPTOR Ethylamine (-)-Varitriol palovarotene 4-ISOPROPYL-1-METHYL-2-PROPENYLBENZENE
1-ISOPROPYL-4-(2-PHENYLVINYL)BENZENE (5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTH-2-YL)METHYLAMINE

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palovarotene 4-[(1E)-2-[5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]benzoic acid Unii-28K6I5m16g R 667 Ro 3300074 (E)-4-(2-(3-((1H-pyrazol-1-yl)Methyl)-5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid Palovarotene(R 667) R 667;RO 3300074 4-[(E)-2-[5,5,8,8-tetramethyl-3-(pyrazol-1-ylmethyl)-6,7-dihydronaphthalen-2-yl]ethenyl]benzoic acid R667;R 667;R667;RO-3300074;RO 3300074;RO3300074 Benzoic acid, 4-[(1E)-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]- Ro 3300074|||R 667 410528-02-8