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ChemicalBook >> CAS DataBase List >> palovarotene

palovarotene

palovarotene price.
  • $81 - $2200
  • Product name: palovarotene
  • CAS: 410528-02-8
  • MF: C27H30N2O2
  • MW: 414.54
  • EINECS:200-258-5
  • MDL Number:MFCD10565968
  • Synonyms:palovarotene;4-[(1E)-2-[5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]benzoic acid;Unii-28K6I5m16g;R 667;Ro 3300074;(E)-4-(2-(3-((1H-pyrazol-1-yl)Methyl)-5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid;Palovarotene(R 667);R 667;RO 3300074
Price19 Properties Safety Information Description
19 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Medical Isotopes, Inc.
  • TRC
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number6589CR
  • Product descriptionPalovarotene
  • Packaging25mg
  • Price$472
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1175
  • Product descriptionPalovarotene
  • Packaging5mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1175
  • Product descriptionPalovarotene
  • Packaging10mg
  • Price$260
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1175
  • Product descriptionPalovarotene
  • Packaging100mg
  • Price$1767
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number28460
  • Product descriptionPalovarotene
  • Packaging5mg
  • Price$81
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28460
  • Product descriptionPalovarotene
  • Packaging10mg
  • Price$152
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number28460
  • Product descriptionPalovarotene
  • Packaging25mg
  • Price$336
  • Updated2024-03-01
  • Buy
  • ManufacturerChemenu
  • Product numberCM141448
  • Product description(E)-4-(2-(3-((1H-pyrazol-1-yl)methyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoicacid 98%
  • Packaging100mg
  • Price$1157
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2031
  • Product descriptionPalovarotene 99.49%
  • Packaging5mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2031
  • Product descriptionPalovarotene 99.49%
  • Packaging10mg
  • Price$260
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2031
  • Product descriptionPalovarotene 99.49%
  • Packaging50mg
  • Price$950
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-2031
  • Product descriptionPalovarotene 99.49%
  • Packaging100mg
  • Price$1600
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001959
  • Product descriptionPalovarotene 98+%
  • Packaging5mg
  • Price$217
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001959
  • Product descriptionPalovarotene 98+%
  • Packaging10mg
  • Price$402
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001959
  • Product descriptionPalovarotene 98+%
  • Packaging100mg
  • Price$1237
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8459
  • Product descriptionPalovarotene(R667) >98%
  • Packaging250mg
  • Price$880
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 6589CR Palovarotene 25mg $472 2021-12-16 Buy
ApexBio Technology B1175 Palovarotene 5mg $160 2021-12-16 Buy
ApexBio Technology B1175 Palovarotene 10mg $260 2021-12-16 Buy
ApexBio Technology B1175 Palovarotene 100mg $1767 2021-12-16 Buy
Cayman Chemical 28460 Palovarotene 5mg $81 2024-03-01 Buy
Cayman Chemical 28460 Palovarotene 10mg $152 2024-03-01 Buy
Cayman Chemical 28460 Palovarotene 25mg $336 2024-03-01 Buy
Chemenu CM141448 (E)-4-(2-(3-((1H-pyrazol-1-yl)methyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoicacid 98% 100mg $1157 2021-12-16 Buy
ChemScene CS-2031 Palovarotene 99.49% 5mg $160 2021-12-16 Buy
ChemScene CS-2031 Palovarotene 99.49% 10mg $260 2021-12-16 Buy
ChemScene CS-2031 Palovarotene 99.49% 50mg $950 2021-12-16 Buy
ChemScene CS-2031 Palovarotene 99.49% 100mg $1600 2021-12-16 Buy
Crysdot CD31001959 Palovarotene 98+% 5mg $217 2021-12-16 Buy
Crysdot CD31001959 Palovarotene 98+% 10mg $402 2021-12-16 Buy
Crysdot CD31001959 Palovarotene 98+% 100mg $1237 2021-12-16 Buy
DC Chemicals DC8459 Palovarotene(R667) >98% 250mg $880 2021-12-16 Buy
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Properties

Melting point :249-252°C
Boiling point :592.3±50.0 °C(Predicted)
Density :1.11
storage temp. :Refrigerator
solubility :DMSO (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated)
pka :4.26±0.10(Predicted)
form :Solid
color :White to Off-White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Palovarotene an orally bioavailable retinoic acid receptor γ (RARγ) agonist. It increases retinoic acid response element (RARE) activity and decreases NF-κB activity induced by IL-1β in primary mouse stromal cells in reporter assays when used at a concentration of 60 nM. Palovarotene (10 nM) inhibits activin A-induced chondrogenic and osteogenic differentiation of mouse fibro/adipogenic progenitors (FAPs) expressing a mutated form of human activin A receptor type I (ACVR1R206H). It inhibits heterotopic ossification and preserves limb movement and growth in a ACVR1R206H fibrodysplasia ossificans progressiva (FOP) mouse model. Palovarotene (1 mg/kg per day for 14 days) decreases heterotopic ossification by 50 to 60% in a rat model of traumatic blast injury.

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Suppliers and manufacturers

career henan chemical co
Palovarotene
$1.00 /1g
Palovarotene CAS:410528-02-8
ATK CHEMICAL COMPANY LIMITED
CONIER CHEM AND PHARMA LIMITED
AFINE CHEMICALS LIMITED
Hefei Hirisun Pharmatech Co., Ltd
Dayang Chem (Hangzhou) Co.,Ltd.
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Nanjing Doge Biomedical Technology Co., Ltd
LEAP CHEM CO., LTD.