Trimethylboroxine
- CAS No.
- 823-96-1
- Chemical Name:
- Trimethylboroxine
- Synonyms
- 2,4,6-triMethyl-1,3,5,2,4,6-trioxatriborinane;2,4,6-Trimethylboroxin;2,4,6-Tr;METHYLBOROXIN;TRIMETHYLBOROXINE;trimethylboroxin,;TRIMEETHYLBOROXINE;Methylboric anhydride;Trimethylcyclotriborane;Methaneboronic anhydride
- CBNumber:
- CB0104810
- Molecular Formula:
- C3H9B3O3
- Molecular Weight:
- 125.53
- MOL File:
- 823-96-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | −38 °C(lit.) |
|---|---|
| Boiling point | 78-80 °C(lit.) |
| Density | 0.898 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 16 °F |
| storage temp. | Flammables area |
| solubility | Chloroform (Sparingly), Dichloromethane (Slightly), THF (Soluble) |
| form | Solution |
| color | Colorless to yellow |
| Water Solubility | Not miscible in water. |
| Sensitive | Moisture Sensitive & Hygroscopic |
| BRN | 1757008 |
| Exposure limits |
ACGIH: TWA 50 ppm; STEL 100 ppm (Skin) OSHA: TWA 200 ppm(590 mg/m3) NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3) |
| InChIKey | GBBSAMQTQCPOBF-UHFFFAOYSA-N |
| CAS DataBase Reference | 823-96-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS02,GHS05,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H314-H335-H351 | |||||||||
| Precautionary statements | P201-P210-P233-P261-P280-P370+P378 | |||||||||
| Hazard Codes | F,C,Xi | |||||||||
| Risk Statements | 11-34-41-37/38-19 | |||||||||
| Safety Statements | 9-16-26-33-36/37/39-45-46-37/39-3 | |||||||||
| RIDADR | UN 2924 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 2-10-21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
Trimethylboroxine price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 903965 | Trimethylboroxine 50% THF solution | 823-96-1 | 5ML | ₹5160.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 903965 | Trimethylboroxine 50% THF solution | 823-96-1 | 25ML | ₹20069.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 903965 | Trimethylboroxine 50% THF solution | 823-96-1 | 250ML | ₹112345.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 323136 | Trimethylboroxine 99% | 823-96-1 | 1G | ₹4319.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 323136 | Trimethylboroxine 99% | 823-96-1 | 5G | ₹13368.88 | 2022-06-14 | Buy |
Trimethylboroxine Chemical Properties,Uses,Production
Chemical Properties
colorless to yellow solution
Uses
Trimethylboroxine is used as a derivatizing agent for GLC analysis. It is used in a diverse array of areas, including as a polymerization additive. It is also used in the preparation of CBS catalysts for asymmetric reductions.
Application
Trimethylboroxine (TMB) is a cyclic anhydride of methyl-boronic acid. It can be been used:
As a derivatizing agent for gas chromatographic/mass spectrometric analysis.
In the preparation of methylaluminoxane (MAO) which is used in the polymerization of olefins.
As an electrolyte additive to enhance the interface stability of electrode/electrolyte.
In methylation of aryl halides by palladium-catalyzed Suzuki-Miyaura coupling reaction.
In the preparation of CBS (Corey, Bakshi and Shibata) catalysts for asymmetric reductions of ketones to alcohols.
Preparation
Trimethylboroxine is prepared by heating B(CH3)3 and B2O3 together in a sealed tube. The B2O3 powder is made by dehydrating H3BO3 under vacuum over P2O5 , at 220℃. The very hygro-scopic oxide is placed with strict exclusion of moisture in a 200-ml. thick-wall Pyrex tube provided with a ground joint, and a melting-point capillary is fastened to the tube just below the joint. The tube is connected to a vacuum pump and immersed in liquid nitrogen, and when a high vacuum has been established, a quantity of B(CH3)3 equivalent to 4.25 g. (0.061 mole) of B2O3 is condensed in the tube. The tube is sealed off, heated to 600℃ and kept at this temperature for six hours; in the process the contents turn into a clear, colorless liquid. When the tube has cooled down, the tip is broken under a nitrogen blanket and sealed to a tube leading to the vacuum pump. The tube is evacuated and the contents of the tube are transferred into a -78℃ trap. The crude product is purified by removing volatile contaminants at -45℃ and then distilling the product from a -10℃ trap into a receiver held at -78℃.
Purification Methods
Possible impurity is methylboronic acid. If present, then add a few drops of conc H2SO4 and distil it immediately, then fractionate it through an efficient column. [McCusker et al. J Am Chem Soc 79 5179 1957, IR: Goubeau & Keller Z Anorg Allgem Chem 272 303 1953, Beilstein 4 IV 4378.]
Structure and conformation
The B and O atoms in trimethylboroxine form a symmetrical six-membered ring.
Trimethylboroxine Preparation Products And Raw materials
Raw materials
Preparation Products
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