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4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester

CAS No.: 1421312-34-6

Chemical Name:: 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester

Synonyms: methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate;Fg6347;ROXA-019;fg-4592 int 2;RSYY(Roxadustat)-17;Fg-4592/FG4592 int 2;Roxastat intermediate;Roxadustat Impurity 34;Roxadustat impurity rst3;Methyl 4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylate

CBNumber:: CB42756260

Molecular Formula:: C18H15NO4

Molecular Weight:: 309.32

MOL File:: 1421312-34-6.mol

Modify Date:: 2024/7/17 16:57:19

Request For Quotation

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Properties

Boiling point	537.3±45.0 °C(Predicted)
Density	1.289±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere, 2-8°C
pka	6.24±0.50(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H302-H315-H335
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Chemical Properties,Uses,Production

Uses

4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid is used as a reagent in the preparation of Roxadustat (H948180), which is a drug used to treat anemia and chronic renal insufficiency.

Preparation

Add 25 g of glacial acetic acid solution containing methyl 1-((dimethylamino)methyl)-4-hydroxy-7-phenoxyisoquinolyl-3-carboxylate into a 1 L four-necked flask which contain 13 g Zinc powder. Then in a stirring state, add 7.5g of 5% dilute hydrochloric acid and raise the temperature to 50-60 ℃. When the raw materials in the liquid phase have basically reacted, reduce the temperature. Filter reaction solution. Rotary evaporated the filtrate obtain 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester (purity: 96.9%, yield: 87.7%).

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Preparation Products And Raw materials

Raw materials

FG-4592 intermediate7 FG-4592 intermediate 8 methyl 1-bromo-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate methyl 1-chloro-4-hydroxy-7-phenoxyisoquinoline-3-carboxylate Methyl boronic acid pinacol ester

FG-4592 interMediate methyl (triphenylphosphoranylidene)acetate Acetyl chloride Dimethyl sulfoxide Trimethylboroxine

TETRAMETHYLTIN Methylboronic acid Methylmagnesium chloride

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Preparation Products

methyl 2-(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxamido)acetate

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Suppliers

Global( 137)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
MANVI BIOPHARMA PVT LTD,	+91-9951015911 +91-9951015911	Hyderabad, India	86	58	Inquiry
CHEMAZON LABORATORIES	+91 9848551964	Hyderabad, India	1320	58	Inquiry
Jiangsu Yutian pharmaceutical Co.,Ltd.	+undefined-0518-86098006 +undefined19851887368	China	80	58	Inquiry
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	China	985	58	Inquiry
ShenZhen H&D Pharmaceutical Technology Co., LTD	+86-0755-22677845 +86-13627253706	China	3154	58	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9337	55	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29897	58	Inquiry
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	CHINA	1320	58	Inquiry
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	China	11667	58	Inquiry

Supplier	Advantage
MANVI BIOPHARMA PVT LTD,	58
CHEMAZON LABORATORIES	58
Jiangsu Yutian pharmaceutical Co.,Ltd.	58
Hangzhou ICH Biofarm Co., Ltd	58
ShenZhen H&D Pharmaceutical Technology Co., LTD	58
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shanghai Yingrui Biopharma Co.,Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58

1421312-34-6(4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester)Related Search:

4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid ethyl ester Roxadustat FG-4592 interMediate

fg-4592 int 2 1 - methyl - 4 - hydroxy - 7 - phenoxy isoquinoline - 3 - methyl formate 4-Hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylic acid methyl ester Fg-4592/FG4592 int 2 ROXA-019 methyl 4-hydroxy-1-methyl-7-pheno1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylic acid xyisoquinoline-3-carboxylate 3-Isoquinolinecarboxylic acid, 4-hydroxy-1-methyl-7-phenoxy-, methyl ester 4-Hydroxy-1-methyl-7-phenoxy-methyl ester-3-isoquinolinecarboxylic Acid Methyl 4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylate Roxadustat Impurity 34 Fg6347 methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylat... methyl 4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carboxylate RSYY(Roxadustat)-17 Roxadustat impurity rst3 Roxastat intermediate 1421312-34-6 API