ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Mitogen-activated protein kinase (MAPK) >Raf inhibitors >GW5074
GW5074
- CAS No.
- 220904-83-6
- Chemical Name:
- GW5074
- Synonyms
- W5074;GW5074;CS-399;GW5074, >=98%;GW-5074;GW 5074;GW5074 USP/EP/BP;GW 5074;GW-5074;GW5074;RAF1 KINASE INHIBITOR I;Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem;3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
- CBNumber:
- CB0130215
- Molecular Formula:
- C15H8Br2INO2
- Molecular Weight:
- 520.94
- MOL File:
- 220904-83-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Boiling point | 561.4±50.0 °C(Predicted) |
|---|---|
| Density | 2.248±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: soluble |
| form | solid |
| pka | 5.86±0.25(Predicted) |
| color | yellow to orange-brown |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChIKey | LMXYVLFTZRPNRV-XCVCLJGOSA-N |
| CAS DataBase Reference | 220904-83-6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
| HS Code | 2933790090 |
GW5074 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | G6416 | GW5074 powder | 220904-83-6 | 5MG | ₹16605.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G6416 | GW5074 powder | 220904-83-6 | 25MG | ₹49795 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 553008 | Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem The Raf1 Kinase Inhibitor I, also referenced under CAS 220904-83-6, controls the biological activity of Raf1 Kinase. This small molecule/inhibitor is | 220904-83-6 | 1MG | ₹19380 | 2022-06-14 | Buy |
GW5074 Chemical Properties,Uses,Production
Uses
GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts, HT-29 colorectal adenocarcinoma cell line and neutrophils.
Biological Activity
Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC 50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm.
Biochem/physiol Actions
GW5074 is a cRaf1 kinase inhibitor, which is placed immediately downstream of Ras in the Motogen activated protein kinase (MAPK) signaling pathway. It elicits protection in GW5074 prevents degeneration in Huntington′s disease and also have therapeutic potential in treating neurodegenerative disorders. GW5074 in combination with anti-inflammatory drug, dexamethasone, attenuates sidestream smoke-induced airway inflammation.
GW5074 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 151)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | China | 694 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24639 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9618 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
220904-83-6(GW5074)Related Search:
RAF1 KINASE INHIBITOR I
(3Z)-3-[(3,5-DIBROMO-4-HYDROXYPHENYL)METHYLIDENE]-5-IODO-1H-INDOL-2-ONE
5-IODO-3-[(3,5-DIBROMO-4-HYDROXYPHENYL)METHYLENE]-2-INDOLINONE
3-(3,5-DIBROMO-4-HYDROXY-BENZYLIDENE)-5-IODO-1,3-DIHYDRO-INDOL-2-ONE
3-(3,5-DIBROMO-4-HYDROXYBENZYLIDINE)-5-IODO-1,3-DIHYDRO-INDOL-2-ONE
GW5074
2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-
3-(3,5-dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
GW5074, >=98%
(Z)-3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
GW-5074;GW 5074
Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem
GW 5074;GW-5074;GW5074
CS-399
W5074
GW5074 USP/EP/BP
3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-2,3-dihydro-1H-indol-2-one
3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
(3E)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
220904-83-6
20904-83-6
C15H8Br2INO2
BioChemical
Cell Signaling and Neuroscience
Cell Biology
Kinase/Phosphatase Biology
Raf
Serine/Threonine Kinase Inhibitors
MAPK
Inhibitors