Ibudilast
- CAS No.
- 50847-11-5
- Chemical Name:
- Ibudilast
- Synonyms
- Ketas;KC-404;AV 411;MN-166;CS-351;Pinatos;Eyevinal;budilast;IBUDILAST;lbudilast
- CBNumber:
- CB0145945
- Molecular Formula:
- C14H18N2O
- Molecular Weight:
- 230.31
- MOL File:
- 50847-11-5.mol
- Modify Date:
- 2024/9/17 21:46:39
| Melting point | 53-54°C |
|---|---|
| Boiling point | 175°C/7.5mmHg(lit.) |
| Density | 1.09 |
| refractive index | 1.5500 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: 28 mg/mL, soluble |
| form | solid |
| pka | 1.22±0.30(Predicted) |
| color | white |
| Merck | 14,4879 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChI | InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3 |
| InChIKey | ZJVFLBOZORBYFE-UHFFFAOYSA-N |
| SMILES | C(C1=C2N(N=C1C(C)C)C=CC=C2)(=O)C(C)C |
| CAS DataBase Reference | 50847-11-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UR0711200 | |||||||||
| HS Code | 2933.99.8290 | |||||||||
| Toxicity | LD50 i.v. in mice: 260 mg/kg (Irikura, 1973) | |||||||||
| NFPA 704 |
|
Ibudilast price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | I0157 | Ibudilast ≥99% (HPLC), solid | 50847-11-5 | 10MG | ₹23440 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | I0157 | Ibudilast ≥99% (HPLC), solid | 50847-11-5 | 50MG | ₹101980 | 2022-06-14 | Buy |
| TCI Chemicals (India) | I0740 | Ibudilast | 50847-11-5 | 20MG | ₹8800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | I0740 | Ibudilast | 50847-11-5 | 100MG | ₹18700 | 2022-05-26 | Buy |
Ibudilast Chemical Properties,Uses,Production
Description
Ibudilast is a leukomene antagonist and phosphodiesterase inhibitor useful in the treatment of bronchial asthma. It antagonizes leukotriene D4-induced contractions of guinea pig ileum and tracheal muscles in virro, and inhibits eosinophil accumulation in vivo.
Chemical Properties
White Solid
Uses
Inhibitors of phosphodiesterase 4 (PDE4), which catalyzes the hydrolysis of cAMP, have potential applications in a variety of diseases, including asthma. Ibudilast is an inhibitor of PDE4 (IC50 = 54-239 nM) that, at higher doses, also inhibits PDE3 and PDE5 (IC50 = 1,600-3,510 nM). Through this action, it suppresses the elaboration of mediators involved in asthma and inflammation.[Cayman Chemical]
Biological Activity
Phosphodiesterase inhibitor (IC 50 values are 53, 35, 48, 12 and 10 mM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.
Ibudilast Preparation Products And Raw materials
Global( 329)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Indogulf Group | 91-22-23455220 | Maharashtra, India | 249 | 58 | Inquiry |
| Enaltec Labs Private Limited | 08108116043 | Mumbai, India | 13 | 58 | Inquiry |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | China | 10991 | 58 | Inquiry |
Related articles
- The application and pharmacologic action of Ibudilast
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- Aug 23，2019
50847-11-5(Ibudilast)Related Search:
IBUDILAST
IBUDILAST-D7
KC-404
1-PROPANONE, 2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]
3-Isobutyryl-2-isopropy-lpyrazolo[1，5-α]pyridine
Ketas
Eyevinal
1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-methyl-1-propanone
Pinatos
Ibudilast,2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404
1-(2-Isopropylpyrazolo[1,5-a]pyridin-3-yl)-2-Methylpropan-1-one
AV 411
Ibudilast (KC-404)
3-ISOBUTYRYL-2-ISOPROPYLPYRAZOLO(1,5-A)PYRIDINE
2-isopropyl-3-isobutyrylpyrazolo[1,5-a]pyridine
2-METHYL-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]-1-PROPANONE
Ibudilast
3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine
2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
Ibudilast, >=98%
budilast
1-propanone 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine KC-404
2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]
3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone
2-methyl-1-(2-(1-methylethyl)pyrazolo(1,5-a)pyridin-3-yl)-1-propanon
5-a)pyridine,3-isobutyryl-2-isopropyl-pyrazolo(
lbudilast
2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404, Ketas
2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-α]pyridin-3-yl]-1-propanone, 3-isobutyrl-2-isopropylpyrazolo[1,5-α]pyridine, KC-404, Ketas
MN-166
CS-351
-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone
Ibudilast>
Ibudilast USP/EP/BP
Ibudilast (KC404, AV411， MN166)
IbudilastQ: What is
Ibudilast Q: What is the CAS Number of
Ibudilast Q: What is the storage condition of
Ibudilast Q: What are the applications of
Ibudilast
50847-11-5
BioChemical
Cell Signaling and Neuroscience
Cell Biology
G Proteins and Cyclic Nucleotides
Phosphodiesterase Inhibitors
Cyclic Nucleotide Metabolism
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals
Cyclic Nucleotide related
Amines
Heterocycles
API