Butorphanol tartrate
![Butorphanol tartrate Structure](CAS/GIF/58786-99-5.gif)
- CAS No.
- 58786-99-5
- Chemical Name:
- Butorphanol tartrate
- Synonyms
- torate;stadol;D00837;Moradol;torbutrol;NIH 10275;Torbugesic;Stadol (tn);oate(1:1)(salt);BUTORPHANOL TARTRATE
- CBNumber:
- CB0181202
- Molecular Formula:
- C25H35NO8
- Molecular Weight:
- 477.55
- MOL File:
- 58786-99-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2022/12/21 16:56:50
Melting point | 217-219° |
---|---|
alpha | D22 -64.0° (c = 0.4 in methanol) |
storage temp. | 2-8°C |
CAS DataBase Reference | 58786-99-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS07,GHS08 |
---|---|
Signal word | Warning |
Hazard statements | H302-H361 |
Precautionary statements | P201-P301+P312+P330-P308+P313 |
Hazard Codes | Xn |
Risk Statements | 22-63 |
Safety Statements | 22-26-36/37/39 |
RIDADR | 1544 |
WGK Germany | 3 |
RTECS | QC7795000 |
HazardClass | 6.1(a) |
PackingGroup | II |
HS Code | 2933492250 |
Toxicity | LD50 in mice, rats (mg/kg): 40-57, 17-20 i.v.; 395-527, 570-756 orally (Heel) |
Butorphanol tartrate Chemical Properties,Uses,Production
Description
Butorphanol (tartrate) (Item No. 23812) is an analytical reference material categorized as an opioid. Butorphanol is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.
Uses
Analgesic; antitussive.
Definition
ChEBI: The (S,S)-tartaric acid salt of butorphanol. It is used for relief or moderate to severe pain.
Mechanism of action
Butorphanol is a strong agonist at κ opioid receptors, and through this interaction, it is five times more potent than morphine as an analgesic. The κagonists have a lower ceiling analgesic effect than full μ agonists; thus, they are not as effective in treating severe pain. Butorphanol is an antagonist at μ opioid receptors with approximately one-sixth the potency of naloxone. If given to a person addicted to a μ agonist, butorphanol will induce an immediate onset of abstinence syndrome.
Side effects
Butorphanol has a different spectrum of side effects than μ opioid analgesics. Respiratory depression occurs. There is a lower ceiling on this effect, however, and it is not generally lethal, as is the case with high doses of μ agonists. Major side effects after normal analgesic doses are sedation, nausea, and sweating, as well as dysphoric (hallucinogenic) effects at higher doses. Butorphanol causes an increase in pulmonary arterial pressure and pulmonary vascular resistance. There is an overall increased workload on the heart, and it should not be used in patients with congestive heart failure or to treat pain from acute myocardial infarction. Butorphanol has low abuse potential and is not a scheduled drug.
Butorphanol tartrate Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
Hikal Ltd. | +91-9538444622 +91-8067356100 | Maharashtra, India | 31 | 58 | Inquiry |
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
Triveni Interchem Private Limited (Group Of Triveni... | 08046042087 | Gujarat, India | 497 | 58 | Inquiry |
Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
Euroasia Trans Continental | +91 22 56349035-36 | New Delhi, India | 519 | 47 | Inquiry |
SRI KRISHNA PHARMACEUTICALS LTD | +91-40-2720 1101 | New Delhi, India | 11 | 58 | Inquiry |
HIKAL LTD | +91-22-6277 0299+91-22-3097 3100 | New Delhi, India | 25 | 58 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
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