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2'-Deoxyguanosine monohydrate

2'-Deoxyguanosine monohydrate Structure
CAS No.
312693-72-4
Chemical Name:
2'-Deoxyguanosine monohydrate
Synonyms
DG;DEOXYGUANOSINE-2';5′-Nucleotides &A-2'-DEOXYGUANOSINE;2'-DEOXY-D-GUANOSINE;Adenosine Impurity 16;GUANINE DESOXYRIBOSIDE;2'-DEOXYGUANOSINE USP/EP/BP;2'-Deoxyguanosine monohydrate;2'-Deoxyguanosine monohydrate
CBNumber:
CB0209021
Molecular Formula:
C10H15N5O5
Molecular Weight:
285.26
MOL File:
312693-72-4.mol
MSDS File:
SDS
Modify Date:
2023/9/20 16:43:00
Request For Quotation

2'-Deoxyguanosine monohydrate Properties

Melting point >300 °C (dec.)(lit.)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility NH4OH 1 M: 50 mg/mL, clear to very faintly turbid, yellow to brown
form powder
pka pK1:2.5(+1) (25°C,μ=0.1)
color White to Off-White
BRN 39814
InChI InChI=1/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6+/s3
InChIKey LZSCQUCOIRGCEJ-FPKZOZHISA-N
SMILES OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)C[C@@H]1O |&1:2,4,17,r|

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264b-P270-P301+P312-P330-P403-P501c
Hazard Codes  Xn,T
Risk Statements  22-25
Safety Statements  45
WGK Germany  3
F  10-23
TSCA  Yes
HS Code  2934999090
NFPA 704
0
2 0

2'-Deoxyguanosine monohydrate price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) D7145 2′-Deoxyguanosine monohydrate 99-100% 312693-72-4 25MG ₹4037.73 2022-06-14 Buy
Sigma-Aldrich(India) D7145 2′-Deoxyguanosine monohydrate 99-100% 312693-72-4 100MG ₹11009.03 2022-06-14 Buy
Sigma-Aldrich(India) D7145 2′-Deoxyguanosine monohydrate 99-100% 312693-72-4 1G ₹58649.85 2022-06-14 Buy
Sigma-Aldrich(India) D7145 2′-Deoxyguanosine monohydrate 99-100% 312693-72-4 5G ₹113835.7 2022-06-14 Buy
Sigma-Aldrich(India) D0901 2′-Deoxyguanosine monohydrate powder, BioReagent, suitable for cell culture, 99-100% 312693-72-4 100MG ₹12318.85 2022-06-14 Buy
Product number Packaging Price Buy
D7145 25MG ₹4037.73 Buy
D7145 100MG ₹11009.03 Buy
D7145 1G ₹58649.85 Buy
D7145 5G ₹113835.7 Buy
D0901 100MG ₹12318.85 Buy

2'-Deoxyguanosine monohydrate Chemical Properties,Uses,Production

Description

2''-Deoxyguanosine is a purine nucleoside with diverse biological activities. It inhibits the clonogenic growth of HL-60 and K562 leukemia cells (IC50s = 80 and 100 μM, respectively). 2''-Deoxyguanosine inhibits the growth of MOLT-4 T cells and MGL-8 B cells by 99.8 and 68.3%, respectively, when used at a concentration of 50 μM. It increases the number of binucleated cells, a marker of inhibited cytokinesis, in A. sativum meristems. 2''-Deoxyguanosine (>1 μM) also induces relaxation of precontracted isolated bovine lingual artery.

Chemical Properties

White to Off-White Solid. Soluble in NH4OH 1 M: 50 mg/mL, clear to very faintly turbid.

Definition

ChEBI: 2'-Deoxyguanosine monohydrate is a purine 2'-deoxyribonucleoside having guanine as the nucleobase. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside. It is functionally related to a guanosine.

Application

2′-Deoxyguanosine monohydrate has been used as a nucleoside supplement:
to study its effect on mitochondrial DNA copy number in deoxyguanosine kinase (dguok) mutant zebrafish,
in tissue culture medium for deoxyribonucleotide triphosphate (dNTP) synthesis,
in RPMI (Roswell Park Memorial Institute)-1640 medium to eliminate the endogenous thymocytes.

Biological Functions

lu et al. found that 2'-Deoxyguanosine (2-dG) is a key immune signaling molecule in plant–microbe interactions and that Arabidopsis VENOSA4 (VEN4) is essential for plant immunity. 2-dG is the immunoreactive component in ZhiNengCong (ZNC). This compound induced classical immune responses, including ROS production, allose accumulation and MPKs phosphorylation, and upregulated the expression of plant immunity-associated genes. In addition, 2-dG-induced plant immunity requires salicylic acid (SA) receptor NPR1 (but not SA), ethylene (ET) signaling, pattern-recognition receptors/coreceptors (PRRs/coreceptors) and the ATP receptor P2K1[1]. VEN4 was involved in 2-dG biosynthesis and could convert dGTP to 2-dG.

References

[1] Chongchong Lu . “Discovery of a novel nucleoside immune signaling molecule 2′-deoxyguanosine in microbes and plants.” Journal of Advanced Research 46 (2023): Pages 1-15.

2'-Deoxyguanosine monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

2'-Deoxyguanosine monohydrate Suppliers

Global( 184)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Orgamine Chemicals(I) Pvt Ltd +91-9820080281 +91-9820080281 Maharashtra, India 451 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Sisco Research Laboratories Pvt. Ltd. +91-22-4268 5800 Mumbai, India 4317 58 Inquiry
Triveni chemicals 08048762458 New Delhi, India 6093 58 Inquiry
Beijing Ribio Biotech Co.,Ltd 010-62664360 +8613328773880 China 117 58 Inquiry
Yunbio Tech Co.,Ltd. +86-010-60605551 +86-18046518538 China 321 58 Inquiry
SHANGHAI NOVRIBO BIOTECH 17821030819 China 73 58 Inquiry
Zhengzhou Chemprize Biotech Co., Ltd. +86-86-0371-56768238 +8615981919713 China 297 58 Inquiry
Hebei Yanxi Chemical Co., Ltd. +86-17531190177; +8617531190177 China 6011 58 Inquiry
Supplier Advantage
Orgamine Chemicals(I) Pvt Ltd 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Sisco Research Laboratories Pvt. Ltd. 58
Triveni chemicals 58
Beijing Ribio Biotech Co.,Ltd 58
Yunbio Tech Co.,Ltd. 58
SHANGHAI NOVRIBO BIOTECH 58
Zhengzhou Chemprize Biotech Co., Ltd. 58
Hebei Yanxi Chemical Co., Ltd. 58

2'-Deoxyguanosine monohydrate Spectrum

2'-Deoxyguanosine monohydrate(312693-72-4)1HNMR

312693-72-4(2'-Deoxyguanosine monohydrate)Related Search:

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ADENYLYL-(3'-5')-GUANOSINE N2-Isobutyryl-2'-deoxyguanosine 2'-Deoxyguanosine-5'-diphosphate trisodium salt N2-ISOBUTYRYL-5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE 2’-deoxyguanosine5’-phosphat
2'-Deoxyguanosine 2’-deoxyguanosine5’-(tetrahydrogentriphosphate 2'-DEOXYGUANOSINE5'-MONOPHOSPHATE,DISODIUM SALT(DGMP·2NA) 5'-O-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE N-ISOBUTYRYL-3'-O-BENZOYL-2'-DEOXYGUANOSINE
8-BROMOGUANOSINE 5'-MONOPHOSPHATE SODIUM SALT 8-MERCAPTOGUANOSINE 2',3',5-TRI-O-ACETYL-8-BROMOGUANOSINE
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2'-DEOXY-D-GUANOSINE 9-(2'-DEOXY-BETA-D-RIBOFURANOSYL)GUANINE A-2'-DEOXYGUANOSINE GUANINE DESOXYRIBOSIDE DEOXYGUANOSINE-2' [1',2',3',4',5'-13C5]2'-deoxyguanosine Monohydrate [2',2''-2H2]2'-deoxyguanosine Monohydrate [3'-2H]2'-deoxyguanosine Monohydrate 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymeth yl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one hydrate 2-Deoxyguanosine Monohydrate extrapure, 99% 5′-Nucleotides & 2'-Deoxyguanosine Monohydrate(2'-dG ? H?O) Adenosine Impurity 16 2'-Deoxyguanosine-[15N5] monohydrate 2'-DEOXYGUANOSINE USP/EP/BP Adenosine Impurity 16（2’ Deoxyguanosine Monohydrate） Biochemical reagent 99% CAS 312693-72-4 2'-Deoxyguanosine monohydrate DG 2'-Deoxyguanosine monohydrate Guanosine, 2'-deoxy-, hydrate (1:1) 2'-DeoxyGuanosine Monohydrate(2'-dG H2O) 2'-deoxy-Guanosine hydrate (1:1) 2'-Deoxyguanosine monohydrate (2'-dG H2O) 2'-DeoxyGuanosine Monohydrate 312693-72-4 C10H13N5O4H20 C10H1315N5O4H2O Specialty Synthesis Oligonucleotide Synthesis Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs Nucleosides DNA / RNA Synthesis BioChemical Biochemicals and Reagents Bases & Related Reagents Carbohydrates & Derivatives Heterocycles Nucleotides