2-Methylpyrazine
- CAS No.
- 109-08-0
- Chemical Name:
- 2-Methylpyrazine
- Synonyms
- Pyrazine, methyl-;METHYLPYRAZINE;3-Methylpyrazine;2-METHYL-1,4-DIAZINE;MPZ;FEMA 3309;FEMA 3616;Methylpiazine;methyl-pyrazin;FEMA NUMBER 3309
- CBNumber:
- CB0237950
- Molecular Formula:
- C5H6N2
- Molecular Weight:
- 94.11
- MOL File:
- 109-08-0.mol
- Modify Date:
- 2024/9/2 13:12:44
| Melting point | -29 °C (lit.) |
|---|---|
| Boiling point | 135 °C/761 mmHg (lit.) |
| Density | 1.03 g/mL at 25 °C (lit.) |
| refractive index |
n |
| FEMA | 3309 | 2-METHYLPYRAZINE |
| Flash point | 122 °F |
| storage temp. | 2-8°C |
| solubility | >20.87 mg/mL in EtOH with ultrasonic; >49.9 mg/mL in DMSO; |
| form | Liquid |
| pka | 1.45(at 27℃) |
| color | Clear colorless to slightly yellow |
| Odor | at 1.00 % in dipropylene glycol. nutty cocoa roasted chocolate peanut green |
| Odor Type | nutty |
| Water Solubility | Fully miscible in water. |
| JECFA Number | 761 |
| BRN | 105778 |
| InChIKey | CAWHJQAVHZEVTJ-UHFFFAOYSA-N |
| LogP | 0.18 |
| CAS DataBase Reference | 109-08-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyrazine, methyl-(109-08-0) |
| EPA Substance Registry System | Pyrazine, methyl- (109-08-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H302 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P301+P312 | |||||||||
| Hazard Codes | Xn,Xi,F | |||||||||
| Risk Statements | 10-22-36/37/38 | |||||||||
| Safety Statements | 26-36-16 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UQ3675000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339990 | |||||||||
| Toxicity | mouse,LD50,intraperitoneal,1820mg/kg (1820mg/kg),Toxicology and Applied Pharmacology. Vol. 17, Pg. 244, 1970. | |||||||||
| NFPA 704 |
|
2-Methylpyrazine price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W330906 | 2-Methylpyrazine ≥99%, FCC, FG | 109-08-0 | 1SAMPLE-K | ₹5141.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W330906 | 2-Methylpyrazine ≥99%, FCC, FG | 109-08-0 | 100G | ₹9233.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W330906 | 2-Methylpyrazine ≥99%, FCC, FG | 109-08-0 | 1KG | ₹16702.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W330906 | 2-Methylpyrazine ≥99%, FCC, FG | 109-08-0 | 5KG | ₹63770.08 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1223 | 2-Methylpyrazine Pharmaceutical Secondary Standard; Certified Reference Material | 109-08-0 | 500MG | ₹8107.93 | 2022-06-14 | Buy |
2-Methylpyrazine Chemical Properties,Uses,Production
Description
2-Methylpyrazine has an odor threshold in water variously reported at 60,000 or 105,000 ppb. May be prepared from the corresponding carboxylic acid; by catalytic dehydrogenation of 2-methyl-piperazine; by condensation of methylglyoxal with ethylenediamine.
Chemical Properties
2-Methylpyrazine has a nutty, cocoa, green, roasted, chocolate, meaty odor.
Occurrence
Reported found in bakery products, roasted barley, cocoa products, coffee, dairy products, cooked meats, peanuts, filberts, pecans, popcorn, potato chips, rum and whiskey, soy product, roasted filberts, roasted almonds, guava, papaya, asparagus, kohlrabi, baked and fried potato, milk, boiled egg, smoked fish, beer, coffee, sesame seed, rice, sukiyaki, buckwheat, sweet corn, corn tortillas, malt, wort, wild rice, okra, crayfish, clam, squid and maté.
Uses
2-Methylpyrazine is used as flavoring agents in bread fresh bread, butter, chocolate, chocolate cocoa, coffee, meat roasted, nut almond.
Preparation
From corresponding carboxylic acid; by catalytic dehydrogenation of 2-methyl-piperazine; by condensation of methylglyoxal with ethylenediamine
General Description
2-Methylpyrazine is an alkyl-substituted pyrazine used as a key intermediate in the synthesis of pyrazineamide, an anti-tubercular drug.
Safety Profile
Moderately toxic by ingestion and intraperitoneal routes. Mutation data reported. Flammable liquid when exposed to heat, sparks, or flame. Can react with oxidizing materials. To fight fire, use water spray, foam, dry chemical, CO2. When heated to decomposition it emits highly toxic fumes of NOx.
Purification Methods
Purify it via the picrate and distil the free base. The picrate has m133-134o(from EtOH). [Wiggins & Wise J Chem Soc 4780 1956, Beilstein 23 III/IV 911, 23/5 V 386.]
2-Methylpyrazine Preparation Products And Raw materials
Raw materials
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| REAX CHEMICALS | +91-9347443900 +91-9347443900 | Hyderabad, India | 169 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| Saibio Pharma | 08068970191Ext 552 | Pune, India | 12 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| REAX CHEMICALS | 58 |
| JSK Chemicals | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Alfa Aesar | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| OCEAN TRADING CORPORATION | 58 |
| Saibio Pharma | 58 |
| Triveni chemicals | 58 |
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