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AEE788

CAS No.: 497839-62-0

Chemical Name:: AEE788

Synonyms: AEE788;CS-375;NVP-AEE788;AEE 788AEE-788;AEE788 USP/EP/BP;AEE788 (NVP-AEE788);AEE788 (NVP-AEE788);AEE-788;AEE 788;NVP-AEE 788;(R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4;6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl) -N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;(R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

CBNumber:: CB02500944

Molecular Formula:: C27H32N6

Molecular Weight:: 440.58

MOL File:: 497839-62-0.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

Request For Quotation

AEE788 Properties

storage temp.	-20°C
solubility	≥22.05 mg/mL in DMSO; insoluble in H2O; ≥14.4 mg/mL in EtOH with ultrasonic
form	powder
color	white to beige
CAS DataBase Reference	497839-62-0

SAFETY

Risk and Safety Statements

RTECS	UY8836200

AEE788 Chemical Properties,Uses,Production

Description

AEE788 is an inhibitor of both epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) receptor tyrosine kinase family members. It can inhibit EGFR and VEGFR tyrosine kinases with IC₅₀ values of 2, 6, 77, and 59 nM for EGFR, ErbB2, KDR, and FLT1, respectively. AEE788 demonstrates antiproliferative activity against a range of EGFR and ErbB2-overexpressing cell lines and can inhibit the proliferation of EGF- and VEGF-stimulated human umbilical vein endothelial cells. It also has been shown to have antitumor and anti-angiogenic activity in numerous animal models of cancer.

Uses

AEE788 is a novel multitargeted human epidermal receptor (HER) 1/2 and vascular endothelial growth factor receptor (VEGFR) 1/2 receptor family tyrosine kinases inhibitor with IC50 of 2, 6, 77, 59 nM for EGFR, ErbB2, KDR, and Flt-1.

AEE788 Preparation Products And Raw materials

Raw materials

Preparation Products

AEE788 Suppliers

Global( 120)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32836	60	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49392	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29825	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24200	58	Inquiry
Finetech Industry Limited	+86-27-87465837 +8618971612321	China	9640	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Finetech Industry Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58

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AEE788 (NVP-AEE788);AEE-788;AEE 788;NVP-AEE 788 (R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4 AEE788 (R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, 6-[4-[(4-ethyl-1-piperazinyl)Methyl]phenyl]-N-[(1R)-1-phenylethyl]- [6-[4-(4-ethyl-piperazine-1-ylMethyl)-phenyl]-7H-pyrrolo[2,3-d]pyrinidinpyriMidin-4-yl]-((R)-1-phenyl-ethyl)-aMine AEE 788AEE-788 [6-[4-[(4-Ethylpiperazin-1-yl)Methyl]phenyl]-7H-pyrrolo[2,3-d]pyriMidin -4-yl]-((R)-1-phenylethyl)aMine AEE788 (NVP-AEE788) NVP-AEE788 6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine AEE 788 AEE788 USP/EP/BP CS-375 6-(4-((4-ethyl-1-piperazinyl)methyl)phenyl)-N-((1R)-1-phenylethyl)-1H-Pyrrolo(2,3-D)pyrimidin-4-amine 6-(4-((4-ethylpiperazin-1-yl)methyl)phenyl) -N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 497839-62-0 Inhibitors Amines Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Tyrosine Kinase Inhibitors