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ML216

ML216 Structure
CAS No.
1430213-30-1
Chemical Name:
ML216
Synonyms
ML216;CS-1561;CID49852229;CID 49852229;CID-49852229;ML216(CID4985229);ML216(CID-49852229);ML 216; ML-216; CID-49852229; CID49852229; CID 49852229;1-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-[5-(4-pyridinyl)-1,3,4-t hiadiazol-2-yl]ure;N-[4-Fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]urea
CBNumber:
CB02715652
Molecular Formula:
C15H9F4N5OS
Molecular Weight:
383.32
MOL File:
1430213-30-1.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:10
Request For Quotation

ML216 Properties

Density 1.583±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO:29.0(Max Conc. mg/mL);75.65(Max Conc. mM)
pka 6.40±0.50(Predicted)
form powder
color light orange to dark orange

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H413
Precautionary statements  P273-P301+P310+P330
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3

ML216 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0661 ML216 ≥98% (HPLC) 1430213-30-1 5MG ₹9190.43 2022-06-14 Buy
Sigma-Aldrich(India) SML0661 ML216 ≥98% (HPLC) 1430213-30-1 25MG ₹36675.1 2022-06-14 Buy
Product number Packaging Price Buy
SML0661 5MG ₹9190.43 Buy
SML0661 25MG ₹36675.1 Buy

ML216 Chemical Properties,Uses,Production

Description

Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom’s Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.

Uses

ML216 has been used in cell proliferation assays.

Biochem/physiol Actions

ML216 is a membrane permeable selective inhibitor of Bloom (BLM) helicase, a member of the RecQ DNA helicase family. Bloom′s syndrome, caused by a mutation in BLM, is associated with susceptibility to cancer, growth retardation, immunodeficiency, sunlight sensitivity, and fertility defects. ML216 is selective for BLM over other members of the RecQ family, especially in vivo, and appears to act at the BLM-nucleic acid substrate binding site, inhibiting DNA binding and blocking BLM′s helicase activity. ML216 could be useful in studies of tumor cells depending on the ALT (alternative lengthening of telomeres) mechanism for telomere maintenance rather than on telomerase, which are proposed to be susceptible to BLM inhibition.

ML216 Preparation Products And Raw materials

Raw materials

Preparation Products

ML216 Suppliers

Global( 77)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Chemtour Biotech Co., Ltd +8617327281506 China 1460 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Wuhan Jingkang en Biomedical Technology Co., Ltd +8613720134139 China 4695 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
InvivoChem 58
TargetMol Chemicals Inc. 58
Chemtour Biotech Co., Ltd 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Aladdin Scientific 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 58
Amadis Chemical Company Limited 58

ML216 Spectrum

ML216(1430213-30-1)1HNMR

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ML216 1-(4-Fluoro-3-(trifluoromethyl)phenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea N-[4-Fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]urea CID 49852229 CID49852229 CID-49852229 ML 216; ML-216; CID-49852229; CID49852229; CID 49852229 CS-1561 ML216(CID-49852229) ML216(CID4985229) 1-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-[5-(4-pyridinyl)-1,3,4-t hiadiazol-2-yl]ure Urea, N-[4-fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]- helicase,CID 49852229,WRN,DNA,sister,inhibit,Anticancer,ML-216,anti-proliferative,DNA/RNA Synthesis,Inhibitor,chromatid,CID49852229,BLM,unwinding,toxicity,ML 216,ML216 1430213-30-1 C15H9F4N5OS