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ML216

ML216 Structure
CAS No.
1430213-30-1
Chemical Name:
ML216
Synonyms
ML216;CS-1561;CID49852229;CID 49852229;CID-49852229;ML216(CID4985229);ML216(CID-49852229);ML216, 10 mM in DMSO;BLM Helicase Inhibitor, ML216;ML 216; ML-216; CID-49852229; CID49852229; CID 49852229
CBNumber:
CB02715652
Molecular Formula:
C15H9F4N5OS
Molecular Weight:
383.32
MOL File:
1430213-30-1.mol
MSDS File:
SDS
Modify Date:
2025/4/17 18:22:24
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ML216 Properties

Density 1.583±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO:29.0(Max Conc. mg/mL);75.65(Max Conc. mM)
pka 6.40±0.50(Predicted)
form powder
color light orange to dark orange

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H413
Precautionary statements  P273-P301+P310+P330
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3

ML216 price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0661 ML216 ≥98% (HPLC) 1430213-30-1 5MG ₹9190.43 2022-06-14 Buy
Sigma-Aldrich(India) SML0661 ML216 ≥98% (HPLC) 1430213-30-1 25MG ₹36675.1 2022-06-14 Buy
Product number Packaging Price Buy
SML0661 5MG ₹9190.43 Buy
SML0661 25MG ₹36675.1 Buy

ML216 Chemical Properties,Uses,Production

Description

Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom’s Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells.

Uses

ML216 has been used in cell proliferation assays.

Biochem/physiol Actions

ML216 is a membrane permeable selective inhibitor of Bloom (BLM) helicase, a member of the RecQ DNA helicase family. Bloom′s syndrome, caused by a mutation in BLM, is associated with susceptibility to cancer, growth retardation, immunodeficiency, sunlight sensitivity, and fertility defects. ML216 is selective for BLM over other members of the RecQ family, especially in vivo, and appears to act at the BLM-nucleic acid substrate binding site, inhibiting DNA binding and blocking BLM′s helicase activity. ML216 could be useful in studies of tumor cells depending on the ALT (alternative lengthening of telomeres) mechanism for telomere maintenance rather than on telomerase, which are proposed to be susceptible to BLM inhibition.

ML216 Preparation Products And Raw materials

Raw materials

Preparation Products

ML216 Suppliers

Global( 87)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
Chengdu Feibo Pharm Technology Co., Ltd +86 028-84641798 15982321820 China 10922 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
TargetMol Chemicals Inc. United States 38630 58 Inquiry
Chemtour Biotech Co., Ltd +8617327281506 China 1521 58 Inquiry
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 China 11681 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8467 58 Inquiry
Aladdin Scientific United States 57505 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
Chengdu Feibo Pharm Technology Co., Ltd 58
TargetMol Chemicals Inc. 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Chemtour Biotech Co., Ltd 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Aladdin Scientific 58

ML216 Spectrum

ML216(1430213-30-1)1HNMR

1430213-30-1(ML216)Related Search:

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ML216 1-(4-Fluoro-3-(trifluoromethyl)phenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea N-[4-Fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]urea CID 49852229 CID49852229 CID-49852229 ML 216; ML-216; CID-49852229; CID49852229; CID 49852229 CS-1561 ML216(CID-49852229) ML216(CID4985229) 1-[4-Fluoro-3-(trifluoromethyl)phenyl]-3-[5-(4-pyridinyl)-1,3,4-t hiadiazol-2-yl]ure Urea, N-[4-fluoro-3-(trifluoromethyl)phenyl]-N'-[5-(4-pyridinyl)-1,3,4-thiadiazol-2-yl]- helicase,CID 49852229,WRN,DNA,sister,inhibit,Anticancer,ML-216,anti-proliferative,DNA/RNA Synthesis,Inhibitor,chromatid,CID49852229,BLM,unwinding,toxicity,ML 216,ML216 ML216, 10 mM in DMSO BLM Helicase Inhibitor, ML216 1430213-30-1 C15H9F4N5OS