KN-93 Phosphate
- CAS No.
- 1188890-41-6
- Chemical Name:
- KN-93 Phosphate
- Synonyms
- CS-1902;KN 93; KN93;KN-93PHOSPHATE;KN-93 phospate;(E)-KN-93 (phosphate);KN-93 phosphate, >=98%;KN 93 Phosphate (E-form);KN-93 Phosphate USP/EP/BP;(E)-N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide phosphate;N-[2-[[[3-(4-Chlorophenyl)-2-propenyl]methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulphonamide phosphate
- CBNumber:
- CB02729653
- Molecular Formula:
- C26H32ClN2O8PS
- Molecular Weight:
- 599.032641
- MOL File:
- 1188890-41-6.mol
- Modify Date:
- 2023/6/30 15:45:59
storage temp. | Inert atmosphere,Room Temperature |
---|---|
solubility |
DMF:25.0(Max Conc. mg/mL);41.73(Max Conc. mM) DMSO:76.67(Max Conc. mg/mL);127.98(Max Conc. mM) Water:49.33(Max Conc. mg/mL);82.35(Max Conc. mM) |
form | White to off-white solid. |
Water Solubility | Soluble in water (10mM) |
CAS DataBase Reference | 1188890-41-6 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05 |
---|---|
Signal word | Danger |
Hazard statements | H314 |
Precautionary statements | P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P405-P501 |
KN-93 Phosphate Chemical Properties,Uses,Production
Description
KN-93 (phosphate) is a potent and selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII) (Ki = 370 nM), inhibiting both the α- and β-subunits of CaMKII. It does not have significant effects on cAMP-dependent protein kinase, Ca2+/phospholipid-dependent protein kinase, myosin light chain kinase, or Ca2+ phosphodiesterase activity. It inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM). KN-93 can block voltage-gated potassium (Kv) channels when applied extracellularly, independent of its CaMKII action. More recently, KN-93 has been used to implicate roles for CaMKII in Ca2+-induced Ca2+ release in cardiac myocytes, constitutive phosphorylation of 5-lipoxygenase in 3T3 cells, and Ca2+-dependent activation of HIF-1α in colon cancer cells.
Uses
KN 93 Phosphate is a potent and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II.
KN-93 Phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24330 | 58 | Inquiry |
InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
Heze Development Zone chuangli Chemical Co., Ltd. | +86-530-529 6766,+86-15666160102 15666160102 | China | 878 | 55 | Inquiry |
Angel Pharmatech, Ltd. | 17317130613 | China | 3250 | 58 | Inquiry |
1188890-41-6(KN-93 Phosphate)Related Search:
1of2
chevron_right