2-Chlorocinnamic acid
- CAS No.
- 3752-25-8
- Chemical Name:
- 2-Chlorocinnamic acid
- Synonyms
- AKOS BBB/195;AKOS B004073;AKOS BBS-00006452;Chlorocinnamicacid;RARECHEM BK HC T319;2-Chlorocinnamicaci;o-chloro-cinnamicaci;2-CLOROCINNAMIC ACID;O-CHLOROCINNAMIC ACID;OTAVA-BB BB0125160239
- CBNumber:
- CB0278409
- Molecular Formula:
- C9H7ClO2
- Molecular Weight:
- 182.6
- MOL File:
- 3752-25-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/29 17:03:55
| Melting point | 208-210 °C(lit.) |
|---|---|
| Boiling point | 260.71°C (rough estimate) |
| Density | 1.2377 (rough estimate) |
| refractive index | 1.5426 (estimate) |
| storage temp. | Room temperature. |
| Water Solubility | Insoluble in water |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | powder to crystal |
| pka | 4.23(at 25℃) |
| color | White to Almost white |
| BRN | 1365198 |
| InChIKey | KJRRTHHNKJBVBO-AATRIKPKSA-N |
| CAS DataBase Reference | 3752-25-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Chlorocinnamic acid(3752-25-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H301-H335 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501-P261-P280a-P301+P310a-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38-22 | |||||||||
| Safety Statements | 36-26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GD8450000 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29124990 | |||||||||
| NFPA 704 |
|
2-Chlorocinnamic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder. Insoluble in water, soluble in ethanol, ethyl acetate and other organic solvents.
Uses
2-Chlorocinnamic acid is a kind of trans-cinnamate. It is used in organic synthesis.
Biological Functions
2-Chlorocinnamic acid is a cinnamic acid derivative that inhibits the hydroxylation of phenylpropanoids. It has been shown to inhibit the activity of cinnamic acid derivatives and their hydroxylation in cell lines, which is linked to the inhibition of cellulose acetate synthesis. 2-Chlorocinnamic acid also has an inhibitory effect on the chloride ion and water molecule. The chloride ion may be needed for the formation of hydrochloric acid, which is necessary for cellulose acetate hydrolysis, while water molecules are involved in many biochemical reactions. 2-Chlorocinnamic acid affects human cell lines at temperatures between 10°C and 37°C and at regiospecific sites. This oxidative dehalogenation reaction catalyzed by R. rubra was found to be regiospecific for 2-chlorocinnamic acid; the chloride ion was probably removed after the ring fission reaction.
Synthesis
O-chlorocinnamic acid is prepared by reacting o-phthalaldehyde with malonic acid.
2-Chlorocinnamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SREE SYNERIC LAB | +91-91-6383636810 +91-9884742764 | Tamil Nadu, India | 465 | 58 | Inquiry |
| Sanovi Pharmaceuticals Pvt Ltd | +91-9900284769 +91-9900284769 | Karnataka, India | 42 | 58 | Inquiry |
| SREE SYNERIC LAB | null | New Delhi, India | 328 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Molecraft LifeSciences Pvt Ltd | +91 (91) 6018-8881 | New Delhi, India | 760 | 0 | Inquiry |
| Biopharmacule Speciality Chemicals P Ltd (India) | +91 40 6462 1866 | Hyderabad, India | 526 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SREE SYNERIC LAB | 58 |
| Sanovi Pharmaceuticals Pvt Ltd | 58 |
| SREE SYNERIC LAB | 58 |
| CHEMSWORTH | 30 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| A.J Chemicals | 58 |
| Reax Chemicals | 58 |
| Molecraft LifeSciences Pvt Ltd | 0 |
| Biopharmacule Speciality Chemicals P Ltd (India) | 58 |
| HiMedia Laboratories | 58 |
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